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• W2952788911 abstract "Abstract Melanoma is responsible for the majority of deaths caused by skin cancer. Antitumor activity of microRNA‐329 (miR‐329) has been seen in several human cancers. In this study, we identify whether miR‐329 serves as a candidate regulator in melanoma. Melanoma‐related differentially expressed genes were screened with its potential molecular mechanism predicted. Melanoma tissues and pigmented nevus tissues were collected, where the levels of miR‐329 and high‐mobility group box 2 (HMGB2) were determined. To characterize the regulatory role of miR‐329 on HMGB2 and the β‐catenin pathway in melanoma cell activities, miR‐329 mimics, miR‐329 inhibitors, and siRNA‐HMGB2 were transfected into melanoma cells. Cell viability, migration, invasion, cell cycle, and apoptosis were assessed. miR‐329 was predicted to influence melanoma by targeting HMGB2 via the β‐catenin pathway. High level of HMGB2 and low miR‐329 expression were observed in melanoma tissues. HMGB2 was targeted and negatively regulated by miR‐329. In melanoma cells transfected with miR‐329 mimics or siRNA‐HMGB2, cell proliferation, migration, and invasion were impeded, yet cell cycle arrest and apoptosis were promoted, corresponding to decreased levels of β‐catenin, cyclin D1, and vimentin and increased levels of GSK3β and E‐cadherin. Collectively, our results show that miR‐329 can suppress the melanoma progression by downregulating HMGB2 via the β‐catenin pathway." @default.
• W2952788911 created "2019-06-27" @default.
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• W2952788911 date "2019-06-20" @default.
• W2952788911 modified "2023-10-17" @default.
• W2952788911 title "MicroRNA‐329 upregulation impairs the HMGB2/β‐catenin pathway and regulates cell biological behaviors in melanoma" @default.
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• W2952788911 doi "https://doi.org/10.1002/jcp.28920" @default.
• W2952788911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31219186" @default.
• W2952788911 hasPublicationYear "2019" @default.
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