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- W2952805790 abstract "A simple one-pot procedure was developed for [3+2]-cycloaddition reactions of α,β-unsaturated aldehydes, diethyl aminomalonate, and aromatic aldehydes in the presence of diphenyl[(2<i>S</i>)-pyrrolidin-2-yl]methanol as catalyst. This reaction converts simple, commercially available, starting materials into densely functionalized polysubstituted pyrrolidines under mild conditions and in a fully stereoselective fashion. Moreover, the use of brine as the reaction medium has remarkable beneficial effects in preventing the formation of self-condensation byproducts, cutting the reaction time, and reducing the production of wastes." @default.
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- W2952805790 date "2013-06-11" @default.
- W2952805790 modified "2023-09-23" @default.
- W2952805790 title "A Simple Synthesis of Polysubstituted Pyrrolidines by an Organocatalytic Three-Component Approach Featuring a One-Pot Condensation and [3+2]-Cycloaddition Reaction in Aqueous Medium" @default.
- W2952805790 doi "https://doi.org/10.1055/s-0033-1338922" @default.
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