FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952806601> ?p ?o ?g. }

• W2952806601 endingPage "351" @default.
• W2952806601 startingPage "351" @default.
• W2952806601 abstract "Heparin or highly sulfated heparan sulfate (HS) has been described in different invertebrates. In ascidians (Chordata-Tunicata), these glycosaminoglycans occur in intracellular granules of oocyte accessory cells and circulating basophil-like cells, resembling mammalian mast cells and basophils, respectively. HS is also a component of the basement membrane of different ascidian organs. We have analyzed an HS isolated from the internal organs of the ascidian Phallusia nigra, using solution 1H/13C NMR spectroscopy, which allowed us to identify and quantify the monosaccharides found in this glycosaminoglycan. A variety of α-glucosamine units with distinct degrees of sulfation and N-acetylation were revealed. The hexuronic acid units occur both as α-iduronic acid and β-glucuronic acid, with variable sulfation at the 2-position. A peculiar structural aspect of the tunicate HS is the high content of 2-sulfated β-glucuronic acid, which accounts for one-third of the total hexuronic acid units. Another distinct aspect of this HS is the occurrence of high content of N-acetylated α-glucosamine units bearing a sulfate group at position 6. The unique ascidian HS is a potent inhibitor of the binding of human colon adenocarcinoma cells to immobilized P-selectin, being 11-fold more potent than mammalian heparin, but almost ineffective as an anticoagulant. Thus, the components of the HS structure required to inhibit coagulation and binding of tumor cells to P-selectin are distinct. Our results also suggest that the regulation of the pathway involved in the biosynthesis of glycosaminoglycans suffered variations during the evolution of chordates." @default.
• W2952806601 created "2019-06-27" @default.
• W2952806601 creator A5005505969 @default.
• W2952806601 creator A5009081722 @default.
• W2952806601 creator A5026216209 @default.
• W2952806601 creator A5026468208 @default.
• W2952806601 creator A5039306800 @default.
• W2952806601 creator A5047132606 @default.
• W2952806601 creator A5049527466 @default.
• W2952806601 creator A5065864399 @default.
• W2952806601 creator A5069507151 @default.
• W2952806601 date "2019-06-12" @default.
• W2952806601 modified "2023-10-03" @default.
• W2952806601 title "Tunicate Heparan Sulfate Enriched in 2-Sulfated β-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin" @default.
• W2952806601 cites W1548090389 @default.
• W2952806601 cites W1577233158 @default.
• W2952806601 cites W1584641354 @default.
• W2952806601 cites W1664827751 @default.
• W2952806601 cites W1915870046 @default.
• W2952806601 cites W1982879414 @default.
• W2952806601 cites W1990991190 @default.
• W2952806601 cites W1994310530 @default.
• W2952806601 cites W2012236903 @default.
• W2952806601 cites W2032255522 @default.
• W2952806601 cites W2036367942 @default.
• W2952806601 cites W2039337035 @default.
• W2952806601 cites W2052769066 @default.
• W2952806601 cites W2067993898 @default.
• W2952806601 cites W2074053750 @default.
• W2952806601 cites W2080182849 @default.
• W2952806601 cites W2097967328 @default.
• W2952806601 cites W2121886286 @default.
• W2952806601 cites W2128474248 @default.
• W2952806601 cites W2129307844 @default.
• W2952806601 cites W2132979663 @default.
• W2952806601 cites W2137583122 @default.
• W2952806601 cites W2138321048 @default.
• W2952806601 cites W2140336796 @default.
• W2952806601 cites W2146477758 @default.
• W2952806601 cites W2149112092 @default.
• W2952806601 cites W2163841415 @default.
• W2952806601 cites W2535070978 @default.
• W2952806601 cites W2759085391 @default.
• W2952806601 cites W2766527793 @default.
• W2952806601 cites W2804083697 @default.
• W2952806601 cites W2417444825 @default.
• W2952806601 doi "https://doi.org/10.3390/md17060351" @default.
• W2952806601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6627333" @default.
• W2952806601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31212795" @default.
• W2952806601 hasPublicationYear "2019" @default.
• W2952806601 type Work @default.
• W2952806601 sameAs 2952806601 @default.
• W2952806601 citedByCount "4" @default.
• W2952806601 countsByYear W29528066012020 @default.
• W2952806601 countsByYear W29528066012021 @default.
• W2952806601 crossrefType "journal-article" @default.
• W2952806601 hasAuthorship W2952806601A5005505969 @default.
• W2952806601 hasAuthorship W2952806601A5009081722 @default.
• W2952806601 hasAuthorship W2952806601A5026216209 @default.
• W2952806601 hasAuthorship W2952806601A5026468208 @default.
• W2952806601 hasAuthorship W2952806601A5039306800 @default.
• W2952806601 hasAuthorship W2952806601A5047132606 @default.
• W2952806601 hasAuthorship W2952806601A5049527466 @default.
• W2952806601 hasAuthorship W2952806601A5065864399 @default.
• W2952806601 hasAuthorship W2952806601A5069507151 @default.
• W2952806601 hasBestOaLocation W29528066011 @default.
• W2952806601 hasConcept C100817775 @default.
• W2952806601 hasConcept C153074725 @default.
• W2952806601 hasConcept C155138218 @default.
• W2952806601 hasConcept C185592680 @default.
• W2952806601 hasConcept C18903297 @default.
• W2952806601 hasConcept C2776648616 @default.
• W2952806601 hasConcept C2777557582 @default.
• W2952806601 hasConcept C2778041096 @default.
• W2952806601 hasConcept C2778125326 @default.
• W2952806601 hasConcept C2779650520 @default.
• W2952806601 hasConcept C2780930470 @default.
• W2952806601 hasConcept C55493867 @default.
• W2952806601 hasConcept C86803240 @default.
• W2952806601 hasConceptScore W2952806601C100817775 @default.
• W2952806601 hasConceptScore W2952806601C153074725 @default.
• W2952806601 hasConceptScore W2952806601C155138218 @default.
• W2952806601 hasConceptScore W2952806601C185592680 @default.
• W2952806601 hasConceptScore W2952806601C18903297 @default.
• W2952806601 hasConceptScore W2952806601C2776648616 @default.
• W2952806601 hasConceptScore W2952806601C2777557582 @default.
• W2952806601 hasConceptScore W2952806601C2778041096 @default.
• W2952806601 hasConceptScore W2952806601C2778125326 @default.
• W2952806601 hasConceptScore W2952806601C2779650520 @default.
• W2952806601 hasConceptScore W2952806601C2780930470 @default.
• W2952806601 hasConceptScore W2952806601C55493867 @default.
• W2952806601 hasConceptScore W2952806601C86803240 @default.
• W2952806601 hasIssue "6" @default.
• W2952806601 hasLocation W29528066011 @default.
• W2952806601 hasLocation W29528066012 @default.
• W2952806601 hasLocation W29528066013 @default.
• W2952806601 hasLocation W29528066014 @default.
• W2952806601 hasLocation W29528066015 @default.

• next