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- W2952806886 abstract "SUMMARY Post-translational modifications hugely increase the functional diversity of proteomes. Recent algorithms based on ultratolerant database searching are forging a path to unbiased analysis of peptide modifications by shotgun mass spectrometry. However, these approaches identify only half of the modified forms potentially detectable and do not map the modified residue. Moreover, tools for the quantitative analysis of peptide modifications are currently lacking. Here, we present a suite of algorithms that allow comprehensive identification of detectable modifications, pinpoint the modified residues, and enable their quantitative analysis through an integrated statistical model. These developments were used to characterize the impact of mitochondrial heteroplasmy on the proteome and on the modified peptidome in several tissues from 12-week old mice. Our results reveal that heteroplasmy mainly affects cardiac tissue, inducing oxidative damage to proteins of the oxidative phosphorylation system, and provide a molecular mechanism that explains the structural and functional alterations produced in heart mitochondria. Highlights Identifies all protein modifications detectable by mass spectrometry Locates the modified site with 85% accuracy Integrates quantitative analysis of the proteome and the modified peptidome Reveals that mtDNA heteroplasmy causes oxidative damage in heart OXPHOS proteins" @default.
- W2952806886 created "2019-06-27" @default.
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- W2952806886 date "2018-04-06" @default.
- W2952806886 modified "2023-10-17" @default.
- W2952806886 title "Comprehensive quantification of the modified proteome reveals oxidative heart damage in mitochondrial heteroplasmy" @default.
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- W2952806886 doi "https://doi.org/10.1101/296392" @default.
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