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• W2952807831 abstract "Interleukin 10 is a central regulator of the antigen-presenting function of myeloid cells. It exerts immunomodulatory effects in vivo and induces a regulatory phenotype in monocyte-derived cells in vitro. We analyzed phenotype and function of monocytic cells in vitro in relation to the cytokine milieu and the timing of TLR-based activation. In GM-CSF/IL-4 cultured human monocytic cells, we identified two, mutually exclusive cell populations arising from undifferentiated cells: CD83+ fully activated dendritic cells and CD14+ macrophage like cells. Re-expression of CD14 occurs primarily after a sequential trigger with a TLR signal following IL-10 preincubation. This cell population with re-expressed CD14 greatly differs in phenotype and function from the CD83+ cells. Detailed analysis of individual subpopulations reveals that exogenous IL-10 is critical for inducing the shift towards the CD14+ population, but does not affect individual changes in marker expression or cell function in most cases. Thus, plasticity of CD14 expression, defining a subset of immunoregulatory cells, is highly relevant for the composition of cellular products (such as DC vaccines) as it affects the function of the total product." @default.
• W2952807831 created "2019-06-27" @default.
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• W2952807831 date "2019-06-28" @default.
• W2952807831 modified "2023-09-26" @default.
• W2952807831 title "Re-expression of CD14 in Response to a Combined IL-10/TLR Stimulus Defines Monocyte-Derived Cells With an Immunoregulatory Phenotype" @default.
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• W2952807831 doi "https://doi.org/10.3389/fimmu.2019.01484" @default.
• W2952807831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6611188" @default.
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• W2952807831 hasPublicationYear "2019" @default.
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