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- W2952807974 abstract "Abstract GLC-MS analysis has been developed for screening plants of the family Solanaceae for new calystegines. GLC-MS analyses of the extract of Scopolia japonica showed the presence of a new tetrahydroxy- nor -tropane alkaloid in addition to the known calystegines A 3 , A 5 , B 1 , B 2 , B 3 , and C 1 . We gave this new alkaloid the trivial name calystegine B 4 . The structure of calystegine B 4 was determined as 1α,2β,3α,4α-tetrahydroxy- nor -tropane from a variety of NMR spectral data. Calystegines B 1 , B 2 , and C 1 are potent competitive inhibitors with K i values ranging from 10 −6 to 10 −7 M for almond β-glucosidase, while calystegine B 4 inhibited this enzyme in a competitive manner, with a K i value of 7.3 μM. Calystegine B 2 is also a potent inhibitor of green coffee bean α-galactosidase, whereas calystegine B 4 exhibited no significant activity for this enzyme. Among rat intestinal glycosidases, only trehalase was potently inhibited by calystegine B 4 , with an IC 50 value of 9.8 μM. Furthermore, calystegine B 4 potently inhibited pig kidney trehalase in a competitive manner, with a K i value of 1.2 μM, but it was almost inactive against yeast and fungal trehalases." @default.
- W2952807974 created "2019-06-27" @default.
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- W2952807974 date "2010-08-04" @default.
- W2952807974 modified "2023-09-26" @default.
- W2952807974 title "ChemInform Abstract: Calystegine B4, a Novel Trehalase Inhibitor from Scopolia japonica" @default.
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- W2952807974 doi "https://doi.org/10.1002/chin.199707242" @default.
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