FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952808888> ?p ?o ?g. }

• W2952808888 abstract "The characterization of functional elements in genomes relies on the identification of the footprints of natural selection. In this quest, taking into account neutral evolutionary processes such as mutation and genetic drift is crucial because these forces can generate patterns that may obscure or mimic signatures of selection. In mammals, and probably in many eukaryotes, another such confounding factor called GC-Biased Gene Conversion (gBGC) has been documented. This mechanism generates patterns identical to what is expected under selection for higher GC-content, specifically in highly recombining genomic regions. Recent results have suggested that a mysterious selective force favouring higher GC-content exists in Bacteria but the possibility that it could be gBGC has been excluded. Here, we show that gBGC is probably at work in most if not all bacterial species. First we find a consistent positive relationship between the GC-content of a gene and evidence of intra-genic recombination throughout a broad spectrum of bacterial clades. Second, we show that the evolutionary force responsible for this pattern is acting independently from selection on codon usage, and could potentially interfere with selection in favor of optimal AU-ending codons. A comparison with data from human populations shows that the intensity of gBGC in Bacteria is comparable to what has been reported in mammals. We propose that gBGC is not restricted to sexual Eukaryotes but also widespread among Bacteria and could therefore be an ancestral feature of cellular organisms. We argue that if gBGC occurs in bacteria, it can account for previously unexplained observations, such as the apparent non-equilibrium of base substitution patterns and the heterogeneity of gene composition within bacterial genomes. Because gBGC produces patterns similar to positive selection, it is essential to take this process into account when studying the evolutionary forces at work in bacterial genomes." @default.
• W2952808888 created "2019-06-27" @default.
• W2952808888 creator A5011691995 @default.
• W2952808888 creator A5036099891 @default.
• W2952808888 creator A5044962997 @default.
• W2952808888 creator A5045841177 @default.
• W2952808888 creator A5051518989 @default.
• W2952808888 creator A5052364369 @default.
• W2952808888 date "2014-11-04" @default.
• W2952808888 modified "2023-10-17" @default.
• W2952808888 title "GC-content evolution in bacterial genomes: the biased gene conversion hypothesis expands." @default.
• W2952808888 cites W104710838 @default.
• W2952808888 cites W1519266993 @default.
• W2952808888 cites W1535669424 @default.
• W2952808888 cites W1925508000 @default.
• W2952808888 cites W1974440260 @default.
• W2952808888 cites W1976065917 @default.
• W2952808888 cites W1982906065 @default.
• W2952808888 cites W1984198684 @default.
• W2952808888 cites W1986196866 @default.
• W2952808888 cites W1989298969 @default.
• W2952808888 cites W2004391041 @default.
• W2952808888 cites W2005360702 @default.
• W2952808888 cites W2007524520 @default.
• W2952808888 cites W2010341755 @default.
• W2952808888 cites W2011645307 @default.
• W2952808888 cites W2012101727 @default.
• W2952808888 cites W2013067928 @default.
• W2952808888 cites W2017026835 @default.
• W2952808888 cites W2026029780 @default.
• W2952808888 cites W2027653803 @default.
• W2952808888 cites W2033159826 @default.
• W2952808888 cites W2043592686 @default.
• W2952808888 cites W2043926219 @default.
• W2952808888 cites W2052903982 @default.
• W2952808888 cites W2069459256 @default.
• W2952808888 cites W2075319493 @default.
• W2952808888 cites W2076219800 @default.
• W2952808888 cites W2091181646 @default.
• W2952808888 cites W2092464006 @default.
• W2952808888 cites W2097548624 @default.
• W2952808888 cites W2100238259 @default.
• W2952808888 cites W2100702435 @default.
• W2952808888 cites W2102104503 @default.
• W2952808888 cites W2102507175 @default.
• W2952808888 cites W2105817668 @default.
• W2952808888 cites W2105871221 @default.
• W2952808888 cites W2108035844 @default.
• W2952808888 cites W2111205680 @default.
• W2952808888 cites W2115622704 @default.
• W2952808888 cites W2117761900 @default.
• W2952808888 cites W2119279196 @default.
• W2952808888 cites W2126627383 @default.
• W2952808888 cites W2130956021 @default.
• W2952808888 cites W2137120669 @default.
• W2952808888 cites W2141344219 @default.
• W2952808888 cites W2142402047 @default.
• W2952808888 cites W2147641903 @default.
• W2952808888 cites W2147838321 @default.
• W2952808888 cites W2148964874 @default.
• W2952808888 cites W2155645165 @default.
• W2952808888 cites W2156789190 @default.
• W2952808888 cites W2162168100 @default.
• W2952808888 cites W2168896194 @default.
• W2952808888 cites W2169812063 @default.
• W2952808888 cites W2169957736 @default.
• W2952808888 cites W2171022989 @default.
• W2952808888 cites W2171667988 @default.
• W2952808888 cites W2593238991 @default.
• W2952808888 cites W2951408456 @default.
• W2952808888 doi "https://doi.org/10.1101/011023" @default.
• W2952808888 hasPublicationYear "2014" @default.
• W2952808888 type Work @default.
• W2952808888 sameAs 2952808888 @default.
• W2952808888 citedByCount "0" @default.
• W2952808888 crossrefType "posted-content" @default.
• W2952808888 hasAuthorship W2952808888A5011691995 @default.
• W2952808888 hasAuthorship W2952808888A5036099891 @default.
• W2952808888 hasAuthorship W2952808888A5044962997 @default.
• W2952808888 hasAuthorship W2952808888A5045841177 @default.
• W2952808888 hasAuthorship W2952808888A5051518989 @default.
• W2952808888 hasAuthorship W2952808888A5052364369 @default.
• W2952808888 hasBestOaLocation W29528088881 @default.
• W2952808888 hasConcept C104317684 @default.
• W2952808888 hasConcept C111472728 @default.
• W2952808888 hasConcept C138885662 @default.
• W2952808888 hasConcept C141231307 @default.
• W2952808888 hasConcept C154945302 @default.
• W2952808888 hasConcept C3742359 @default.
• W2952808888 hasConcept C41008148 @default.
• W2952808888 hasConcept C42251679 @default.
• W2952808888 hasConcept C44465124 @default.
• W2952808888 hasConcept C54355233 @default.
• W2952808888 hasConcept C7386963 @default.
• W2952808888 hasConcept C75268714 @default.
• W2952808888 hasConcept C78458016 @default.
• W2952808888 hasConcept C81917197 @default.
• W2952808888 hasConcept C86803240 @default.
• W2952808888 hasConcept C89611455 @default.
• W2952808888 hasConcept C90132467 @default.

• next