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- W2952826324 abstract "Sepsis is a multifaceted host response to infection that dramatically affects patient outcomes and the cost of health care. Animal models are necessary to replicate the complexity and heterogeneity of clinical sepsis. However, these models entail a high risk of pain and distress due to tissue trauma, inflammation, endotoxin-mediated hyperalgesia, and other mechanisms. Several recent studies and initiatives address the need to improve the welfare of animals through analgesics and standardize the models used in preclinical sepsis research. Ultimately, the goal is to provide high-fidelity, humane animal models that better replicate the clinical course of sepsis, to provide more effective translation and advance therapeutic discovery. The purpose of this review is to discuss the current understanding of the roles of pain and analgesia in rodent models of sepsis. The current definitions of sepsis along with an overview of pain in human sepsis are described. Finally, welfare concerns associated with animal models of sepsis and the most recent considerations for relief of pain and distress are reviewed." @default.
- W2952826324 created "2019-06-27" @default.
- W2952826324 creator A5008863485 @default.
- W2952826324 creator A5020229055 @default.
- W2952826324 creator A5044534111 @default.
- W2952826324 creator A5077694770 @default.
- W2952826324 date "2019-12-01" @default.
- W2952826324 modified "2023-10-03" @default.
- W2952826324 title "The Influence of Pain and Analgesia in Rodent Models of Sepsis" @default.
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