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- W2952833175 abstract "In order to design a new parenteral 1beta-methylcarbapenem antibiotic which has a broad antibacterial spectrum and improved plasma half-life, a series of 1beta-methylcarbapenems with 5-substituted pyrrolidine-3-ylthio groups including an amidine moiety at the C-2 position have been synthesized and structure-activity relationships were investigated. Among those carbapenem derivatives, CS-023 (R-115685) showed a broad spectrum and excellent antibacterial activity against Gram-positive and Gram-negative bacteria. This compound also showed sufficient dehydropeptidase-I (DHP-I) stability and high urinary recovery in animals after subcutaneous administration without cilastatin, a DHP-I inhibitor. Based on these characteristics, CS-023 was selected for further study." @default.
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- W2952833175 date "2003-11-25" @default.
- W2952833175 modified "2023-09-25" @default.
- W2952833175 title "Synthesis and Structure—Activity Relationships of Novel Parenteral Carbapenems, CS-023 (R-115685) and Related Compounds Containing an Amidine Moiety." @default.
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- W2952833175 doi "https://doi.org/10.1002/chin.200347229" @default.
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