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- W2952853082 abstract "Abstract MicroRNAs (miRNAs), the potential regulator of adipogenesis, markedly characterized by lipid droplet (LD) formation, play an important role in progenitor‐cell differentiation into adipocytes. In recent years, it has excited interests in regulation of miRNAs in adipogenesis. However, no study is available, to our knowledge, regarding the expression of miRNAs on LD formation. Our study provides the first insight into the expression profiling of the miRNA targeting messenger RNAs (mRNAs) involving with LD formation during adipogenesis from human mesenchymal stem cells by RNA‐Seq transcriptome technique. It showed that 39, 105, 194, and 112 differentially expressed miRNA appeared at 7, 14, 21, and 28 days, respectively, for LD formation during adipogenesis. Nineteen miRNAs targeted 35 mRNA associated with LDs formation. Except for the known miRNA hsa‐miR‐1908 regulating adipogenesis, five miRNAs, including hsa‐miR‐146a‐3p, hsa‐miR‐4495, hsa‐miR‐4663, hsa‐miR‐6069, and hsa‐miR‐675‐3p are the latest potential biomarkers for LD formation, targeting ACSL1, APOB, METTL7A, PLIN1, and PLIN4. A comprehensive transcriptome profiling of miRNA reveals the regulatory relationship between miRNA and mRNA relating to LD formation during adipogenesis. Such candidates may represent biomarkers and therapeutic targets for metabolic syndromes like obesity, type‐2 diabetes, steatosis, atherosclerosis, and osteoporosis." @default.
- W2952853082 created "2019-06-27" @default.
- W2952853082 creator A5003553247 @default.
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- W2952853082 date "2019-06-18" @default.
- W2952853082 modified "2023-10-06" @default.
- W2952853082 title "The key microRNA on lipid droplet formation during adipogenesis from human mesenchymal stem cells" @default.
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- W2952853082 cites W1974951213 @default.
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- W2952853082 cites W1981332939 @default.
- W2952853082 cites W1983304890 @default.
- W2952853082 cites W1984246348 @default.
- W2952853082 cites W1986509730 @default.
- W2952853082 cites W1986946985 @default.
- W2952853082 cites W2002076968 @default.
- W2952853082 cites W2008977230 @default.
- W2952853082 cites W2010430872 @default.
- W2952853082 cites W2014946489 @default.
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- W2952853082 cites W2027846112 @default.
- W2952853082 cites W2031853603 @default.
- W2952853082 cites W2038180405 @default.
- W2952853082 cites W2043129312 @default.
- W2952853082 cites W2043234667 @default.
- W2952853082 cites W2047914188 @default.
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- W2952853082 doi "https://doi.org/10.1002/jcp.28972" @default.
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