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- W2952893993 abstract "A concise and enantioselective synthesis of (S)-ethyl 2-cyclopentyl-2-hydroxy-2-arylacetate, a key intermediate for the muscarinic receptor, is reported. The tertiary stereogenic center was constructed with good stereoselectivity through the L-proline-catalyzed direct asymmetric aldol reaction of ethyl arylglyoxylate and cyclopentanone. The carbonyl of the condensation product was reduced using a modified Clemmensen reaction which provided an easier workup and was more environmentally acceptable. The enantioselectivity of the aldol reactions was between 58.3%–93.2%, which means that the stereoselective is efficient in controlling configuration of reaction product." @default.
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- W2952893993 date "2010-04-29" @default.
- W2952893993 modified "2023-10-17" @default.
- W2952893993 title "Enantioselective Aldol Reaction of α-Ketoester and Cyclopentaone Catalyzed by L-Proline" @default.
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- W2952893993 doi "https://doi.org/10.1002/cjoc.201090122" @default.
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