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• W2952912485 abstract "A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 (JTV-803) exhibited potent inhibitory activity against FXa and good selectivity with respect to other serine proteases (thrombin, plasmin, and trypsin). In addition, compound 2 exhibited potent anti-FXa activity after intravenous and oral administration to cynomolgus monkey, and showed a dose-dependent antithrombotic effect in a rat model of venous thrombosis." @default.
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• W2952912485 date "2005-01-01" @default.
• W2952912485 modified "2023-10-11" @default.
• W2952912485 title "Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors" @default.
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• W2952912485 doi "https://doi.org/10.1016/j.bmcl.2004.10.033" @default.
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