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- W2952913305 abstract "A convenient method of synthesizing tetrasubstituted olefins as single isomers is described. E-β-Chloro-α-iodo-α,β-unsaturated esters are first converted into the corresponding E-β-chloro-α,β-unsaturated esters using Suzuki–Miyaura coupling reactions with arylboronic acids and alkenylboronic acids. These transformations gave complete selectivity, and proceeded with substitution at the more activated α-iodide position. These compounds, isolated as single isomers, were then transformed into tetrasubstituted olefins by Suzuki–Miyaura couplings with arylboronic acids, alkenylboronic acids, and alkyl boranes to afford the corresponding tetrasubstituted olefins as single isomers. During this coupling process, it was discovered that the use of small ligands, such as PMe3 or PEt3, was critical for efficient coupling. The stereochemistry and regiochemistry of the products were unequivocally established using NMR methods." @default.
- W2952913305 created "2019-06-27" @default.
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- W2952913305 date "2008-06-01" @default.
- W2952913305 modified "2023-09-23" @default.
- W2952913305 title "A simple method to prepare single isomer tetrasubstituted olefins by successive Suzuki–Miyaura cross-couplings of E-β-chloro-α-iodo-α,β-unsaturated esters" @default.
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- W2952913305 doi "https://doi.org/10.1016/j.tet.2008.04.004" @default.
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