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- W2952913686 abstract "<b><i>Background:</i></b> Mean platelet volume (MPV) may be a useful biomarker for platelet activation in obese patients. However, storage duration and use of anticoagulant K3-ethylenediaminetetraacetic acid (EDTA) may interfere with these measurements. <b><i>Objectives:</i></b> The aim of this study was to measure the variability of MPV in obese patients following exposure to EDTA. <b><i>Method:</i></b> A total of 160 patients were divided into 3 groups according to body mass index (BMI; normal: <25 kg/m<sup>2</sup>; overweight: 25–30 kg/m<sup>2</sup>; obese: >30 kg/m<sup>2</sup>). Blood was collected in sterile tubes containing K3-EDTA. Blood cell counts were obtained using the CELL-DYN Ruby system immediately and 1, 2, and 3 h after collection. <b><i>Results:</i></b> MPV was found to be directly proportional to BMI. With the addition of EDTA, MPV was increased in the first hour after collection; MPV then decreased to levels that were lower than initial baseline measurements. <b><i>Conclusions:</i></b> K3-EDTA use alters platelet volume. The time from collection to measurement should be standardized to reduce MPV value variance. MPV should be determined within 1 h of collection to avoid anticoagulant use-related interference." @default.
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- W2952913686 date "2019-01-01" @default.
- W2952913686 modified "2023-09-26" @default.
- W2952913686 title "Analysis of Post-Sample Collection EDTA Effects on Mean Platelet Volume Values in Relation to Overweight and Obese Patient Status" @default.
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- W2952913686 doi "https://doi.org/10.1159/000499101" @default.
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