Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952926332> ?p ?o ?g. }
- W2952926332 abstract "Integrating virus-host interactions with host protein-protein interactions, we have created a method using these established network practices to identify host factors (i.e., proteins) that are likely candidates for antiviral drug targeting. We demonstrate that interaction cascades between host proteins that directly interact with viral proteins and host factors that are important to influenza virus replication are enriched for signaling and immune processes. Additionally, we show that host proteins that interact with viral proteins are in network locations of power. Finally, we demonstrate a new network methodology to predict novel host factors and validate predictions with an siRNA screen. Our results show that integrating virus-host proteins interactions is useful in the identification of antiviral drug target candidates." @default.
- W2952926332 created "2019-06-27" @default.
- W2952926332 creator A5004759835 @default.
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- W2952926332 date "2018-12-21" @default.
- W2952926332 modified "2023-10-17" @default.
- W2952926332 title "Network-Guided Discovery of Influenza Virus Replication Host Factors" @default.
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- W2952926332 doi "https://doi.org/10.1128/mbio.02002-18" @default.
- W2952926332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6299219" @default.
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- W2952926332 hasPublicationYear "2018" @default.
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