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• W2952934410 abstract "Several promising live attenuated dengue vaccines are in development, but information about innate immune responses and early correlates of protection is lacking.We characterized human genome-wide transcripts in whole blood from 10 volunteers at 11 time points after immunization with the dengue virus type 3 (DENV-3) component of the National Institutes of Health dengue vaccine candidate TV003 and from 30 hospitalized children with acute primary DENV-3 infection. We compared day-specific gene expression patterns with subsequent neutralizing antibody (NAb) titers.The transcriptional response to vaccination was largely confined to days 5-20 and was dominated by an interferon-associated signature and a cell cycle signature that peaked on days 8 and 14, respectively. Changes in transcript abundance were much greater in magnitude and scope in symptomatic natural infection than following vaccination (maximum fold-change >200 vs 21 postvaccination; 3210 vs 286 transcripts with significant fold-change), but shared gene modules were induced in the same sequence. The abundances of 131 transcripts on days 8 and 9 postvaccination were strongly correlated with NAb titers measured 6 weeks postvaccination.Live attenuated dengue vaccination elicits early transcriptional responses that mirror those found in symptomatic natural infection and provide candidate early markers of protection against DENV infection.NCT00831012." @default.
• W2952934410 created "2019-06-27" @default.
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• W2952934410 date "2018-07-14" @default.
• W2952934410 modified "2023-10-17" @default.
• W2952934410 title "Early Transcriptional Responses After Dengue Vaccination Mirror the Response to Natural Infection and Predict Neutralizing Antibody Titers" @default.
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• W2952934410 doi "https://doi.org/10.1093/infdis/jiy434" @default.
• W2952934410 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6217718" @default.
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