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- W2952938248 abstract "A series of 1,n-alkanediylbis(1,4-dihydropyridines) (n = 2, 4, 6, 8, 10, 12) bridged at C3 of 2,6-dimethyl-3-carboxy-5-carbethoxy-4-(3-nitrophenyl)-1,4-dihydropyridin e were synthesized and evaluated in a radioligand binding assay, [3H]nitrendipine in intestinal smooth muscle, as Ca2+ channel ligands. Binding activity was comparable to that of nitrendipine itself but independent of chain length, suggesting the lack of a major binding contribution by the second 1,4-dihydropyridine group. Analogues lacking the second 1,4-dihydropyridine nucleus or possessing an inactive function (4-nitrophenyl) were no less active, confirming that this series of ligands likely does not bridge adjacent 1,4-dihydropyridine receptors of the Ca2+ channel." @default.
- W2952938248 created "2019-06-27" @default.
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- W2952938248 date "1989-01-24" @default.
- W2952938248 modified "2023-09-26" @default.
- W2952938248 title "ChemInform Abstract: Dimeric 1,4-Dihydropyridines as Calcium Channel Antagonists." @default.
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- W2952938248 doi "https://doi.org/10.1002/chin.198904194" @default.
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