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• W2952955480 abstract "In the Avocado Sunblotch Viroid (ASBVd: 249-nt) from the Avsunviroidae family, a symmetric rolling-circle replication operates through an autocatalytic mechanism mediated by hammerhead ribozymes (HHR) embedded in both polarity strands. The concatenated multimeric ASBVd (+) and ASBVd (-) RNAs thus generated are processed by cleavage to unit-length where ASBVd (-) self-cleaves with more efficiency. Absolute scale small angle neutron scattering (SANS) revealed a temperature-dependent dimer association in both ASBVd (-) and its derived 79-nt HHR (-). A joint thermodynamic analysis of SANS and catalytic data indicates the rate-determining step corresponds to the dimer/monomer transition. 2D and 3D models of monomeric and dimeric HHR (-) suggest that the inter-molecular contacts stabilizing the dimer (between HI and HII domains) compete with the intra-molecular ones stabilizing the active conformation of the full-length HHR required for an efficient self-cleavage. Similar competing intra- and inter-molecular contacts are proposed in ASBVd (-) though with a remoter region from an extension of the HI domain." @default.
• W2952955480 created "2019-06-27" @default.
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• W2952955480 date "2016-07-26" @default.
• W2952955480 modified "2023-10-18" @default.
• W2952955480 title "Self-assembly Controls Self-cleavage of HHR from ASBVd (−): a Combined SANS and Modeling Study" @default.
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• W2952955480 doi "https://doi.org/10.1038/srep30287" @default.
• W2952955480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4960562" @default.
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