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- W2952976530 abstract "The choanoflagellate Salpingoeca rosetta is a microbial marine eukaryote that can switch between unicellular and multicellular states. As one of the closest living relatives of animals, this organism has become a model for understanding how multicellularity evolved in the animal lineage. Previously our laboratories isolated and synthesized a bacterially produced sulfonolipid that induces S. rosetta to form multicellular “rosettes.” In this study, we report the identification of a bacterially produced inhibitor of rosettes (IOR-1) as well as the total synthesis of this molecule and all of its stereoisomers. Our results confirm the previously noted specificity and potency of rosette-modulating molecules, expand our understanding of the complex chemical ecology between choanoflagellates and rosette-inducing bacteria, and provide a synthetic probe template for conducting further mechanistic studies on the emergence of multicellularity." @default.
- W2952976530 created "2019-06-27" @default.
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- W2952976530 date "2016-08-01" @default.
- W2952976530 modified "2023-09-27" @default.
- W2952976530 title "ChemInform Abstract: Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates." @default.
- W2952976530 cites W2310757528 @default.
- W2952976530 doi "https://doi.org/10.1002/chin.201636186" @default.
- W2952976530 hasPublicationYear "2016" @default.
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