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• W2952997321 abstract "A central role for damage to cochlear primary afferent synapses has been demonstrated in various auditory pathologies. Similarly, the selective lesioning of primary vestibular synapses may be an underlying cause of peripheral vestibulopathies that cause vertigo and dizziness, for which the pathophysiology is currently unknown. To thoroughly address this possibility, we selectively damaged the synaptic contacts between hair cells and primary vestibular neurons in mice through the transtympanic administration of a glutamate receptor agonist. Using a combination of histological and functional approaches, we demonstrated that 1) selective synaptic deafferentation is sufficient to generate acute vestibular syndrome with characteristics similar to those reported in patients; 2) the reduction of the vestibulo-ocular reflex and posturo-locomotor deficits mainly depends on spared synapses; 3) damaged primary vestibular synapses are able to be repaired over the days and weeks following deafferentation; and 4) the synaptic repair process occurs through the re-expression and re-pairing of synaptic proteins such as CtBP2 and SHANK-1. Primary synapse repair may contribute to re-establishing the initial sensory network. Deciphering the molecular mechanism that supports synaptic repair may offer a therapeutic opportunity to rescue full vestibular input and restore gait and balance in patients." @default.
• W2952997321 created "2019-06-27" @default.
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• W2952997321 date "2019-01-01" @default.
• W2952997321 modified "2023-10-16" @default.
• W2952997321 title "Morphological and functional correlates of vestibular synaptic deafferentation and repair in a mouse model of acute onset vertigo" @default.
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• W2952997321 doi "https://doi.org/10.1242/dmm.039115" @default.
• W2952997321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6679379" @default.
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• W2952997321 hasPublicationYear "2019" @default.
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