Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953002803> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2953002803 abstract "Recently, the entomopathogenic fungus Polycephalomyces nipponicus has been determined to be a prolific producer of bioactive compounds that have both antibacterial and antimarial activities, but the anticancer effects of the mycelial extracts have not been well studied. The present study investigates the effects and mechanisms of action of P. nipponicus extracts that are responsible for cell death in the human breast cancer MCF-7 cell line. The results showed that the 50% ethanol extract had greater anticancer activity than the aqueous extract. The 50% ethanolic extract inhibited cell growth at concentrations of just 109.75 ± 3.54 µg mL-1 for 72 h. The aqueous extract's activity was > 400 µg mL-1 against MCF-7 cells. Similar results were obtained from the colony formation assay. Moreover, the 50% ethanolic extract caused a significant increase in the distribution of cells at the G1 phase in a dose-dependent manner. The aqueous extract induced MCF-7 cells to arrest at the G2/M phase in a dose-dependent manner. These were supported by the reduction in the cyclin-dependent kinase (cdk)2, cdk4, and cdk6 genes' expression levels along with an induction of the cyclin-dependent kinase inhibitor p21 in MCF-7 cells after treatment with the extracts. In conclusion, P. nipponicus may be useful for breast cancer prevention and treatment in the future." @default.
- W2953002803 created "2019-06-27" @default.
- W2953002803 creator A5002720558 @default.
- W2953002803 creator A5045433314 @default.
- W2953002803 creator A5072828183 @default.
- W2953002803 date "2019-01-01" @default.
- W2953002803 modified "2023-10-02" @default.
- W2953002803 title "Comparative Study on the Effect of Aqueous and Ethanolic Mycelial Extracts from Polycephalomyces nipponicus (Ascomycetes) against Human Breast Cancer MCF-7 Cells" @default.
- W2953002803 doi "https://doi.org/10.1615/intjmedmushrooms.2019031140" @default.
- W2953002803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31679301" @default.
- W2953002803 hasPublicationYear "2019" @default.
- W2953002803 type Work @default.
- W2953002803 sameAs 2953002803 @default.
- W2953002803 citedByCount "2" @default.
- W2953002803 countsByYear W29530028032020 @default.
- W2953002803 countsByYear W29530028032021 @default.
- W2953002803 crossrefType "journal-article" @default.
- W2953002803 hasAuthorship W2953002803A5002720558 @default.
- W2953002803 hasAuthorship W2953002803A5045433314 @default.
- W2953002803 hasAuthorship W2953002803A5072828183 @default.
- W2953002803 hasConcept C109541995 @default.
- W2953002803 hasConcept C121608353 @default.
- W2953002803 hasConcept C124320809 @default.
- W2953002803 hasConcept C133479454 @default.
- W2953002803 hasConcept C185592680 @default.
- W2953002803 hasConcept C190283241 @default.
- W2953002803 hasConcept C199649820 @default.
- W2953002803 hasConcept C29537977 @default.
- W2953002803 hasConcept C2994423619 @default.
- W2953002803 hasConcept C54355233 @default.
- W2953002803 hasConcept C55493867 @default.
- W2953002803 hasConcept C556039675 @default.
- W2953002803 hasConcept C59822182 @default.
- W2953002803 hasConcept C71924100 @default.
- W2953002803 hasConcept C86803240 @default.
- W2953002803 hasConcept C96232424 @default.
- W2953002803 hasConcept C98274493 @default.
- W2953002803 hasConceptScore W2953002803C109541995 @default.
- W2953002803 hasConceptScore W2953002803C121608353 @default.
- W2953002803 hasConceptScore W2953002803C124320809 @default.
- W2953002803 hasConceptScore W2953002803C133479454 @default.
- W2953002803 hasConceptScore W2953002803C185592680 @default.
- W2953002803 hasConceptScore W2953002803C190283241 @default.
- W2953002803 hasConceptScore W2953002803C199649820 @default.
- W2953002803 hasConceptScore W2953002803C29537977 @default.
- W2953002803 hasConceptScore W2953002803C2994423619 @default.
- W2953002803 hasConceptScore W2953002803C54355233 @default.
- W2953002803 hasConceptScore W2953002803C55493867 @default.
- W2953002803 hasConceptScore W2953002803C556039675 @default.
- W2953002803 hasConceptScore W2953002803C59822182 @default.
- W2953002803 hasConceptScore W2953002803C71924100 @default.
- W2953002803 hasConceptScore W2953002803C86803240 @default.
- W2953002803 hasConceptScore W2953002803C96232424 @default.
- W2953002803 hasConceptScore W2953002803C98274493 @default.
- W2953002803 hasLocation W29530028031 @default.
- W2953002803 hasLocation W29530028032 @default.
- W2953002803 hasOpenAccess W2953002803 @default.
- W2953002803 hasPrimaryLocation W29530028031 @default.
- W2953002803 hasRelatedWork W2024613292 @default.
- W2953002803 hasRelatedWork W2171353487 @default.
- W2953002803 hasRelatedWork W2182606779 @default.
- W2953002803 hasRelatedWork W2613512289 @default.
- W2953002803 hasRelatedWork W2744242902 @default.
- W2953002803 hasRelatedWork W2803215897 @default.
- W2953002803 hasRelatedWork W2803827619 @default.
- W2953002803 hasRelatedWork W2811000545 @default.
- W2953002803 hasRelatedWork W2904792517 @default.
- W2953002803 hasRelatedWork W2916041877 @default.
- W2953002803 hasRelatedWork W2916315841 @default.
- W2953002803 hasRelatedWork W2948642792 @default.
- W2953002803 hasRelatedWork W2994353399 @default.
- W2953002803 hasRelatedWork W3005617091 @default.
- W2953002803 hasRelatedWork W3014254561 @default.
- W2953002803 hasRelatedWork W3107681891 @default.
- W2953002803 hasRelatedWork W3114265118 @default.
- W2953002803 hasRelatedWork W3159217094 @default.
- W2953002803 hasRelatedWork W88004580 @default.
- W2953002803 hasRelatedWork W2184694547 @default.
- W2953002803 isParatext "false" @default.
- W2953002803 isRetracted "false" @default.
- W2953002803 magId "2953002803" @default.
- W2953002803 workType "article" @default.