FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953002904> ?p ?o ?g. }

• W2953002904 abstract "Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20-50% of patients. Clinical failure of talc pleurodesis is thought to be due to poor dispersion. This monograph reports the development of a foam delivery system designed to more effectively coat the pleural cavity.C57BL/6 mice were injected with Lewis lung carcinoma (LL/2) cells intrapleurally to induce MPE. The mice then received either normal saline (NS) control, foam control (F), talc slurry (TS, 2 mg/g) or talc foam (TF, 2 mg/g). Airspace volume was evaluated by CT, lungs/pleura were collected, and percent fibrosis was determined.The TF group had significantly better survival than the TS group (21 vs 13.5 days, p < 0.0001). The average effusion volume was less in the talc groups compared to the control group (140 vs 628 μL, p < 0.001). TF induced significant lung fibrosis (p < 0.01), similar to TS. On CT, TF significantly (p < 0.05) reduced loss of right lung volume (by 30-40%) compared to the control group. This was not seen with TS (p > 0.05).This report describes using a novel talc foam delivery system for the treatment of MPE. In the LL/2 model, mice treated with the TF had better survival outcomes and less reduction of lung volume than mice treated with the standard of care TS. These data provide support for translational efforts to move talc foam from animal models into clinical trials." @default.
• W2953002904 created "2019-06-27" @default.
• W2953002904 creator A5003483571 @default.
• W2953002904 creator A5004302234 @default.
• W2953002904 creator A5008243378 @default.
• W2953002904 creator A5027142788 @default.
• W2953002904 creator A5051505926 @default.
• W2953002904 creator A5056008968 @default.
• W2953002904 creator A5064274343 @default.
• W2953002904 creator A5073496606 @default.
• W2953002904 creator A5077438335 @default.
• W2953002904 date "2019-06-24" @default.
• W2953002904 modified "2023-10-18" @default.
• W2953002904 title "An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion" @default.
• W2953002904 cites W1691766376 @default.
• W2953002904 cites W1850591271 @default.
• W2953002904 cites W1963469729 @default.
• W2953002904 cites W1975166857 @default.
• W2953002904 cites W1991493240 @default.
• W2953002904 cites W2002851265 @default.
• W2953002904 cites W2122738461 @default.
• W2953002904 cites W2130171825 @default.
• W2953002904 cites W2146585105 @default.
• W2953002904 cites W2147481343 @default.
• W2953002904 cites W2279413142 @default.
• W2953002904 cites W2346044936 @default.
• W2953002904 cites W2367198992 @default.
• W2953002904 cites W2415138112 @default.
• W2953002904 cites W2466883271 @default.
• W2953002904 cites W2527905628 @default.
• W2953002904 cites W2570618306 @default.
• W2953002904 cites W2615272510 @default.
• W2953002904 cites W2635951006 @default.
• W2953002904 cites W2751449255 @default.
• W2953002904 cites W2753432434 @default.
• W2953002904 cites W2757756125 @default.
• W2953002904 cites W2795716722 @default.
• W2953002904 cites W2805413615 @default.
• W2953002904 cites W2811143555 @default.
• W2953002904 cites W2884284882 @default.
• W2953002904 cites W2894749894 @default.
• W2953002904 cites W4251854788 @default.
• W2953002904 cites W2051198745 @default.
• W2953002904 doi "https://doi.org/10.1186/s12885-019-5777-z" @default.
• W2953002904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6589887" @default.
• W2953002904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31234819" @default.
• W2953002904 hasPublicationYear "2019" @default.
• W2953002904 type Work @default.
• W2953002904 sameAs 2953002904 @default.
• W2953002904 citedByCount "2" @default.
• W2953002904 countsByYear W29530029042020 @default.
• W2953002904 countsByYear W29530029042021 @default.
• W2953002904 crossrefType "journal-article" @default.
• W2953002904 hasAuthorship W2953002904A5003483571 @default.
• W2953002904 hasAuthorship W2953002904A5004302234 @default.
• W2953002904 hasAuthorship W2953002904A5008243378 @default.
• W2953002904 hasAuthorship W2953002904A5027142788 @default.
• W2953002904 hasAuthorship W2953002904A5051505926 @default.
• W2953002904 hasAuthorship W2953002904A5056008968 @default.
• W2953002904 hasAuthorship W2953002904A5064274343 @default.
• W2953002904 hasAuthorship W2953002904A5073496606 @default.
• W2953002904 hasAuthorship W2953002904A5077438335 @default.
• W2953002904 hasBestOaLocation W29530029041 @default.
• W2953002904 hasConcept C126322002 @default.
• W2953002904 hasConcept C141071460 @default.
• W2953002904 hasConcept C142724271 @default.
• W2953002904 hasConcept C159985019 @default.
• W2953002904 hasConcept C163430725 @default.
• W2953002904 hasConcept C192562407 @default.
• W2953002904 hasConcept C2776232967 @default.
• W2953002904 hasConcept C2776256026 @default.
• W2953002904 hasConcept C2776979038 @default.
• W2953002904 hasConcept C2777397205 @default.
• W2953002904 hasConcept C2777714996 @default.
• W2953002904 hasConcept C2779634585 @default.
• W2953002904 hasConcept C2779979586 @default.
• W2953002904 hasConcept C2781244666 @default.
• W2953002904 hasConcept C71924100 @default.
• W2953002904 hasConcept C90924648 @default.
• W2953002904 hasConceptScore W2953002904C126322002 @default.
• W2953002904 hasConceptScore W2953002904C141071460 @default.
• W2953002904 hasConceptScore W2953002904C142724271 @default.
• W2953002904 hasConceptScore W2953002904C159985019 @default.
• W2953002904 hasConceptScore W2953002904C163430725 @default.
• W2953002904 hasConceptScore W2953002904C192562407 @default.
• W2953002904 hasConceptScore W2953002904C2776232967 @default.
• W2953002904 hasConceptScore W2953002904C2776256026 @default.
• W2953002904 hasConceptScore W2953002904C2776979038 @default.
• W2953002904 hasConceptScore W2953002904C2777397205 @default.
• W2953002904 hasConceptScore W2953002904C2777714996 @default.
• W2953002904 hasConceptScore W2953002904C2779634585 @default.
• W2953002904 hasConceptScore W2953002904C2779979586 @default.
• W2953002904 hasConceptScore W2953002904C2781244666 @default.
• W2953002904 hasConceptScore W2953002904C71924100 @default.
• W2953002904 hasConceptScore W2953002904C90924648 @default.
• W2953002904 hasFunder F4320332161 @default.
• W2953002904 hasFunder F4320337351 @default.
• W2953002904 hasIssue "1" @default.
• W2953002904 hasLocation W29530029041 @default.
• W2953002904 hasLocation W29530029042 @default.

• next