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- W2953003896 endingPage "1362" @default.
- W2953003896 startingPage "1350" @default.
- W2953003896 abstract "Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases. It is becoming clear that epigenetic modification playing an essential role in determining the biological behavior of cells. In particular, changes of DNA methylation, histone methylation and acetylation regulated by the corresponding epigenetic enzymes, can directly control macrophages differentiation and change their functions under different conditions. In addition, epigenetic enzymes also have become anti-tumor targets, such as HDAC, LSD1, DNMT, and so on. In this review, we presented an overview of the latest progress in the study of macrophages phenotype and function regulated by epigenetic modifications, including DNA methylation and histone modifications, to better understand how epigenetic modification controls macrophages phenotype and function in inflammation-associated diseases, and the application prospect in anti-tumor." @default.
- W2953003896 created "2019-06-27" @default.
- W2953003896 creator A5021140829 @default.
- W2953003896 creator A5043670679 @default.
- W2953003896 creator A5043853158 @default.
- W2953003896 creator A5045364810 @default.
- W2953003896 creator A5054180910 @default.
- W2953003896 creator A5069555206 @default.
- W2953003896 date "2019-09-03" @default.
- W2953003896 modified "2023-10-15" @default.
- W2953003896 title "Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy" @default.
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