FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953008462> ?p ?o ?g. }

• W2953008462 endingPage "e196126" @default.
• W2953008462 startingPage "e196126" @default.
• W2953008462 abstract "<h3>Importance</h3> Changes in estradiol during aging are associated with increased dementia risk. It remains unclear how estradiol supports cognitive health and whether risk factors, such as midlife obesity, are exacerbated by estrogen loss. <h3>Objectives</h3> To assess whether visceral adipose tissue (VAT) moderates the association between age and brain network structure and to investigate whether estradiol moderates the association between VAT and brain network structure. <h3>Design, Setting, and Participants</h3> Cross-sectional study of data from 974 cognitively healthy adults in Germany who participated in the Health Study of the Leipzig Research Centre for Civilization Diseases, a previously described population-based cohort study. Two moderation analyses were performed, including VAT as the moderator variable between age and brain network structure and estradiol as the moderator variable between VAT and brain network structure. The study was conducted from August 1, 2011, to November 23, 2014. Analyses were conducted from August 2017 to September 2018. <h3>Exposures</h3> Serum estradiol levels from fasting blood and visceral adipose tissue volume from T1-weighted magnetic resonance imaging (MRI). <h3>Main Outcomes and Measures</h3> Brain network covariance (individual loading on structural network derived from T1-weighted MRI) and memory performance (composite score from the Consortium to Establish a Registry for Alzheimer Disease [CERAD] verbal episodic memory test on learning [score range, 0-30], recall [score range, 0-10], and recognition [score range, 0-20]). <h3>Results</h3> Final analyses included data from 473 women (mean [SD] age, 50.10 [15.63] years) and 501 men (mean [SD] age, 51.24 [15.67] years). Visceral adipose tissue was associated with an exacerbation of the negative association of aging with network covariance for women (interaction term β = −0.02; 95% bias-corrected bootstrap CI, −0.03 to −0.01;<i>P</i> = .001) and men (interaction term β = −0.02; 95% bias-corrected bootstrap CI, −0.03 to −0.01;<i>P</i> < .001). Estradiol level was associated with a reduction in the negative association of VAT with network covariance in women (interaction term β = 0.63; 95% bias-corrected bootstrap CI, 0.14-1.12;<i>P</i> = .01), with no significant association in men. In the female midlife subgroup (age range, 35-55 years, when menopause transition occurs), low estradiol levels were associated with lower memory network covariance (Cohen<i>d</i> = 0.61;<i>t</i>₈₀ = 2.76;<i>P</i> = .007) and worse memory performance (Cohen<i>d</i> = 0.63;<i>t</i>₇₆ = 2.76;<i>P</i> = .007). <h3>Conclusions and Relevance</h3> This study reports a novel association between VAT, estradiol, and structural brain networks as a potential mechanism underlying cognitive decline in women. These findings appear to highlight the need for sex-specific strategies, including VAT and hormonal screening during midlife, to support healthy cognitive aging." @default.
• W2953008462 created "2019-06-27" @default.
• W2953008462 creator A5002201058 @default.
• W2953008462 creator A5010133468 @default.
• W2953008462 creator A5011402411 @default.
• W2953008462 creator A5020270555 @default.
• W2953008462 creator A5029768023 @default.
• W2953008462 creator A5038291686 @default.
• W2953008462 creator A5045258788 @default.
• W2953008462 creator A5053898553 @default.
• W2953008462 creator A5059436450 @default.
• W2953008462 creator A5063715734 @default.
• W2953008462 creator A5065567566 @default.
• W2953008462 creator A5069571418 @default.
• W2953008462 creator A5082637425 @default.
• W2953008462 creator A5084424614 @default.
• W2953008462 creator A5089011159 @default.
• W2953008462 date "2019-06-21" @default.
• W2953008462 modified "2023-09-24" @default.
• W2953008462 title "Association of Estradiol and Visceral Fat With Structural Brain Networks and Memory Performance in Adults" @default.
• W2953008462 cites W1514533495 @default.
• W2953008462 cites W1548058762 @default.
• W2953008462 cites W1588434295 @default.
• W2953008462 cites W1913092771 @default.
• W2953008462 cites W1917578869 @default.
• W2953008462 cites W1971797728 @default.
• W2953008462 cites W1975082124 @default.
• W2953008462 cites W1980508061 @default.
• W2953008462 cites W1985198009 @default.
• W2953008462 cites W1985567099 @default.
• W2953008462 cites W1986568472 @default.
• W2953008462 cites W1994239403 @default.
• W2953008462 cites W1996347185 @default.
• W2953008462 cites W2001848626 @default.
• W2953008462 cites W2002752208 @default.
• W2953008462 cites W2004430285 @default.
• W2953008462 cites W2007635035 @default.
• W2953008462 cites W2020031936 @default.
• W2953008462 cites W2034897558 @default.
• W2953008462 cites W204352528 @default.
• W2953008462 cites W2049397413 @default.
• W2953008462 cites W2050566788 @default.
• W2953008462 cites W2051714598 @default.
• W2953008462 cites W2057042201 @default.
• W2953008462 cites W2059796825 @default.
• W2953008462 cites W2064963539 @default.
• W2953008462 cites W2069147780 @default.
• W2953008462 cites W2070869214 @default.
• W2953008462 cites W2078524519 @default.
• W2953008462 cites W2078604986 @default.
• W2953008462 cites W2086225923 @default.
• W2953008462 cites W2086630609 @default.
• W2953008462 cites W2092496538 @default.
• W2953008462 cites W2096407616 @default.
• W2953008462 cites W2096465668 @default.
• W2953008462 cites W2097776282 @default.
• W2953008462 cites W2097799979 @default.
• W2953008462 cites W2098850229 @default.
• W2953008462 cites W2102009612 @default.
• W2953008462 cites W2103069600 @default.
• W2953008462 cites W2109095584 @default.
• W2953008462 cites W2109694442 @default.
• W2953008462 cites W2109876897 @default.
• W2953008462 cites W2118275843 @default.
• W2953008462 cites W2119473645 @default.
• W2953008462 cites W2122522567 @default.
• W2953008462 cites W2124956656 @default.
• W2953008462 cites W2127720974 @default.
• W2953008462 cites W2134458253 @default.
• W2953008462 cites W2136294475 @default.
• W2953008462 cites W2140493318 @default.
• W2953008462 cites W2157134970 @default.
• W2953008462 cites W2157296433 @default.
• W2953008462 cites W2158766477 @default.
• W2953008462 cites W2159203244 @default.
• W2953008462 cites W2162510673 @default.
• W2953008462 cites W2216073902 @default.
• W2953008462 cites W2597201456 @default.
• W2953008462 cites W2791568464 @default.
• W2953008462 cites W2793260524 @default.
• W2953008462 cites W4206679801 @default.
• W2953008462 cites W4235259561 @default.
• W2953008462 cites W4241362057 @default.
• W2953008462 doi "https://doi.org/10.1001/jamanetworkopen.2019.6126" @default.
• W2953008462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593958" @default.
• W2953008462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31225892" @default.
• W2953008462 hasPublicationYear "2019" @default.
• W2953008462 type Work @default.
• W2953008462 sameAs 2953008462 @default.
• W2953008462 citedByCount "27" @default.
• W2953008462 countsByYear W29530084622020 @default.
• W2953008462 countsByYear W29530084622021 @default.
• W2953008462 countsByYear W29530084622022 @default.
• W2953008462 countsByYear W29530084622023 @default.
• W2953008462 crossrefType "journal-article" @default.
• W2953008462 hasAuthorship W2953008462A5002201058 @default.
• W2953008462 hasAuthorship W2953008462A5010133468 @default.
• W2953008462 hasAuthorship W2953008462A5011402411 @default.

• next