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• W2953014014 abstract "Abstract 103 Pd seed is being used for prostate brachytherapy. Additionally, the dose enhancement effect of gold nanoparticles (GNP) has been reported in previous studies. The aim of this study was to characterize the dosimetric effect of gold nanoparticles in brachytherapy with a 103 Pd source. Two brachytherapy seeds including 103 Pd source was simulated using MCNPX Monte Carlo code. The seeds’ models were validated by comparing the MC with reported results. Then, GNPs (10 nm in diameter) with a concentration of 7mg Au/g were simulated uniformly inside the prostate of a humanoid computational phantom. Additionally, the dose enhancement factor (DEF) of nanoparticles was calculated for both modeled brachytherapy seeds. A good agreement was found between the MC calculated and the reported dosimetric parameters. For both seeds, an average DEF of 23% was obtained in tumor volume for prostate brachytherapy. The application of GNPs in conjunction with 103 Pd seed in brachytherapy can enhance the delivered dose to the tumor and consequently leads to better treatment outcome." @default.
• W2953014014 created "2019-06-27" @default.
• W2953014014 creator A5014755351 @default.
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• W2953014014 date "2019-06-01" @default.
• W2953014014 modified "2023-09-24" @default.
• W2953014014 title "A Monte Carlo study on the radio-sensitization effect of gold nanoparticles in brachytherapy of prostate by ¹⁰³Pd seeds" @default.
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• W2953014014 doi "https://doi.org/10.2478/pjmpe-2019-0012" @default.
• W2953014014 hasPublicationYear "2019" @default.
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