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- W2953018797 abstract "Abstract Purpose : Strategies for the design and synthesis of boronated nucleosides, amino acids, and peptides as potential delivery agents for boron neutron capture therapy (BNCT) are described. Methods and Materials : For BNCT to be a useful treatment modality, there is a need to design and synthesize nontoxic boron compounds that selectively target tumor cells, accumulate insufficient amounts (20–30 μg 10B/g of tumor) and persist at therapeutic levels for a sufficient time prior to neutron irradiation. Boronated nucleosides, amino acids and peptides are such promising target compounds. Such structures may be selectively used by proliferating neoplastic cells compared with mitotically less active normal cells and therefore achieve the tissue differentials necessary for BNCT. Results : The rationale for synthesis of boronated nucleic acid and protein components is discussed. Results of biological and clinical studies of some boronated nucleosides, nucleotides, amino acids and peptides are presented. Conclusion : Boronated nucleosides, amino acids and peptides can be considered as potential targeting agents for BNCT." @default.
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- W2953018797 date "2010-08-18" @default.
- W2953018797 modified "2023-09-25" @default.
- W2953018797 title "ChemInform Abstract: Strategies for the Design and Synthesis of Boronated Nucleic Acid and Protein Components as Potential Delivery Agents for Neutron Capture Therapy" @default.
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- W2953018797 doi "https://doi.org/10.1002/chin.199440297" @default.
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