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• W2953034100 abstract "<b>Background:</b> Thrombopoietin (TPO) is regulated by a feedback mechanism between megakaryocytes and platelets. This is important in plateletpheresis donors to compensate for donation-associated platelet loss.<br><b>Aims and Objectives:</b> The aim and objective of this study were to investigate changes in serum TPO levels in healthy plateletpheresis donors and its correlation with platelet recovery pattern.<br><b>Materials and Methods:</b> Out of 50 plateletpheresis donors recruited in the study over 1 year, only 29 completed follow-up and were further analyzed. Plateletpheresis procedures were performed on two types of cell separators (TRIMA ACCEL^®, Terumo BCT Lakewood Colorado and AMICUS^®, Fresenius Kabi, Germany). Platelet parameters were estimated pre- and post-platelet donation, at 3^rd- and 5^th-day postdonation. Serum TPO levels were determined using quantitative sandwich enzyme-linked immunosorbent assay technique (Raybiotech, USA) as per the protocol of the manufacturer.<br><b>Results:</b> The majority of donors (72%) in our study were first-time donors. The baseline platelet count was 226 ± 44 × 10³/μl with a significant decline (30%; <i>P</i> < 0.001) in postdonation phase and remained below baseline on the 3^rd and 5^th day. The serum TPO levels increased significantly (<i>P</i> < 0.001) from a baseline of 227.81 (interquartile range [IQR]: 176.06) pg/ml to 269.94 (IQR: 110.68) pg/ml postdonation and remained elevated from baseline levels on the 3^rd and 5^th day. An inverse relation was observed between change in serum TPO levels and platelet count during postdonation phase which was not statistically significant (<i>P</i> > 0.05).<br><b>Conclusion:</b> Serum TPO levels increase significantly post plateletpheresis donation corresponding to decrease in platelet counts showing that TPO plays a vital role in compensatory mechanism after platelet loss." @default.
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• W2953034100 date "2019-01-01" @default.
• W2953034100 modified "2023-10-17" @default.
• W2953034100 title "Effect of plateletpheresis on postdonation serum thrombopoietin levels and its correlation with platelet counts in healthy voluntary donors" @default.
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• W2953034100 doi "https://doi.org/10.4103/ajts.ajts_86_18" @default.
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