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• W2953035310 abstract "Heritability analyses of GWAS cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here, we analyze the genetic architecture of schizophrenia in 49,806 samples from the PGC, and nine complex diseases in 54,734 samples from the GERA cohort. For schizophrenia, we infer an overwhelmingly polygenic disease architecture in which ≥71% of 1Mb genomic regions harbor at least one variant influencing schizophrenia risk. We also observe significant enrichment of heritability in GC-rich regions and in higher-frequency SNPs for both schizophrenia and GERA diseases. In bivariate analyses, we observe significant genetic correlations (ranging from 0.18 to 0.85) among several pairs of GERA diseases; genetic correlations were on average 1.3x stronger than correlations of overall disease liabilities. To accomplish these analyses, we developed a fast algorithm for multi-component, multi-trait variance components analysis that overcomes prior computational barriers that made such analyses intractable at this scale." @default.
• W2953035310 created "2019-06-27" @default.
• W2953035310 creator A5010910777 @default.
• W2953035310 creator A5011961838 @default.
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• W2953035310 creator A5076245323 @default.
• W2953035310 creator A5087357204 @default.
• W2953035310 creator A5088603132 @default.
• W2953035310 date "2015-03-14" @default.
• W2953035310 modified "2023-10-18" @default.
• W2953035310 title "Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis" @default.
• W2953035310 cites W1517808374 @default.
• W2953035310 cites W1523454857 @default.
• W2953035310 cites W1565240145 @default.
• W2953035310 cites W191324832 @default.
• W2953035310 cites W1920021112 @default.
• W2953035310 cites W1952660301 @default.
• W2953035310 cites W1966775465 @default.
• W2953035310 cites W1968990062 @default.
• W2953035310 cites W1976587387 @default.
• W2953035310 cites W1977104259 @default.
• W2953035310 cites W1978150238 @default.
• W2953035310 cites W1983539381 @default.
• W2953035310 cites W1986818660 @default.
• W2953035310 cites W1987493079 @default.
• W2953035310 cites W1991704577 @default.
• W2953035310 cites W1992747978 @default.
• W2953035310 cites W1993849755 @default.
• W2953035310 cites W1996682563 @default.
• W2953035310 cites W1997887791 @default.
• W2953035310 cites W2000084758 @default.
• W2953035310 cites W2002752296 @default.
• W2953035310 cites W2023947090 @default.
• W2953035310 cites W2024290635 @default.
• W2953035310 cites W2027837618 @default.
• W2953035310 cites W2030993345 @default.
• W2953035310 cites W2031090940 @default.
• W2953035310 cites W2031999522 @default.
• W2953035310 cites W2032311106 @default.
• W2953035310 cites W2033151532 @default.
• W2953035310 cites W2034046719 @default.
• W2953035310 cites W2037238692 @default.
• W2953035310 cites W2039153962 @default.
• W2953035310 cites W2045008815 @default.
• W2953035310 cites W2045227722 @default.
• W2953035310 cites W2046094312 @default.
• W2953035310 cites W2049633694 @default.
• W2953035310 cites W2067715889 @default.
• W2953035310 cites W2070589766 @default.
• W2953035310 cites W2073456954 @default.
• W2953035310 cites W2075793174 @default.
• W2953035310 cites W2079927753 @default.
• W2953035310 cites W2080235308 @default.
• W2953035310 cites W2081067541 @default.
• W2953035310 cites W2090075367 @default.
• W2953035310 cites W2096472676 @default.
• W2953035310 cites W2098143048 @default.
• W2953035310 cites W2098597355 @default.
• W2953035310 cites W2098601118 @default.
• W2953035310 cites W2099085143 @default.
• W2953035310 cites W2101357408 @default.
• W2953035310 cites W2102213696 @default.
• W2953035310 cites W2102687347 @default.
• W2953035310 cites W2102802796 @default.
• W2953035310 cites W2103181374 @default.
• W2953035310 cites W2113381731 @default.
• W2953035310 cites W2113758182 @default.
• W2953035310 cites W2115807273 @default.
• W2953035310 cites W2117180217 @default.
• W2953035310 cites W2119279196 @default.
• W2953035310 cites W2120807753 @default.
• W2953035310 cites W2125972459 @default.
• W2953035310 cites W2127684760 @default.
• W2953035310 cites W2128738903 @default.
• W2953035310 cites W2139852278 @default.
• W2953035310 cites W2142847239 @default.
• W2953035310 cites W2146415150 @default.
• W2953035310 cites W2148749248 @default.
• W2953035310 cites W2148985208 @default.
• W2953035310 cites W2153037482 @default.
• W2953035310 cites W2153118028 @default.
• W2953035310 cites W2153245297 @default.
• W2953035310 cites W2153968413 @default.
• W2953035310 cites W2154763555 @default.
• W2953035310 cites W2155496693 @default.
• W2953035310 cites W2158802660 @default.
• W2953035310 cites W2159417227 @default.
• W2953035310 cites W2161527093 @default.
• W2953035310 cites W2165807758 @default.
• W2953035310 cites W2168018259 @default.
• W2953035310 cites W2169471788 @default.
• W2953035310 cites W2344504388 @default.

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