FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953037600> ?p ?o ?g. }

• W2953037600 endingPage "548" @default.
• W2953037600 startingPage "541" @default.
• W2953037600 abstract "Molecular recognition of the amphiphilic electron carrier ubiquinone (Q) by respiratory complexes is a fundamental part of electron transfer chains in mitochondria and bacteria. The primary respiratory complex I binds Q in a long and narrow protein chamber to catalyse its reduction. But, the binding mechanism and the role of chamber hydration in substrate selectivity and stability are unclear. Here, large-scale atomistic molecular dynamics simulations and estimated free energy profiles are used to characterize in detail the binding mechanism to complex I of Q with short and with long isoprenoid tails. A highly stable binding site with two different poses near the chamber exit and a secondary reactive site near the N2 iron-sulfur cluster are found which may lead to an alternative Q redox chemistry and help to explain complex I reactivity. The binding energetics depends mainly on polar interactions of the Q-head and on the counterbalanced hydration of Q-tail isoprenoid units and hydrophobic residues inside the protein chamber. Selectivity upon variation of tail length arises by shifting the hydration balance. This internal hydration mechanism may have implications for binding of amphiphilic molecules to cavities in other membrane proteins." @default.
• W2953037600 created "2019-06-27" @default.
• W2953037600 creator A5002609699 @default.
• W2953037600 creator A5072664409 @default.
• W2953037600 date "2019-07-01" @default.
• W2953037600 modified "2023-10-02" @default.
• W2953037600 title "Balanced internal hydration discriminates substrate binding to respiratory complex I" @default.
• W2953037600 cites W1031578623 @default.
• W2953037600 cites W1521381364 @default.
• W2953037600 cites W1965129659 @default.
• W2953037600 cites W1965662719 @default.
• W2953037600 cites W1965997818 @default.
• W2953037600 cites W1967751997 @default.
• W2953037600 cites W1970257190 @default.
• W2953037600 cites W1973318584 @default.
• W2953037600 cites W1976314697 @default.
• W2953037600 cites W1976499671 @default.
• W2953037600 cites W1978680299 @default.
• W2953037600 cites W1987120082 @default.
• W2953037600 cites W1998404217 @default.
• W2953037600 cites W2003651998 @default.
• W2953037600 cites W2005238912 @default.
• W2953037600 cites W2006283486 @default.
• W2953037600 cites W2011301426 @default.
• W2953037600 cites W2013090060 @default.
• W2953037600 cites W2019356464 @default.
• W2953037600 cites W2026286713 @default.
• W2953037600 cites W2035266068 @default.
• W2953037600 cites W2035672721 @default.
• W2953037600 cites W2047375078 @default.
• W2953037600 cites W2054993869 @default.
• W2953037600 cites W2057477511 @default.
• W2953037600 cites W2058570690 @default.
• W2953037600 cites W2065283382 @default.
• W2953037600 cites W2066414494 @default.
• W2953037600 cites W2067174909 @default.
• W2953037600 cites W2070275592 @default.
• W2953037600 cites W2073623394 @default.
• W2953037600 cites W2083037765 @default.
• W2953037600 cites W2084818794 @default.
• W2953037600 cites W2094575480 @default.
• W2953037600 cites W2095216354 @default.
• W2953037600 cites W2109154308 @default.
• W2953037600 cites W2109853992 @default.
• W2953037600 cites W2119707316 @default.
• W2953037600 cites W2128572087 @default.
• W2953037600 cites W2130210612 @default.
• W2953037600 cites W2146411229 @default.
• W2953037600 cites W2162027701 @default.
• W2953037600 cites W2165012926 @default.
• W2953037600 cites W2165526004 @default.
• W2953037600 cites W2170957707 @default.
• W2953037600 cites W2221239255 @default.
• W2953037600 cites W2296756275 @default.
• W2953037600 cites W2314489782 @default.
• W2953037600 cites W2334653157 @default.
• W2953037600 cites W2507191366 @default.
• W2953037600 cites W2507486477 @default.
• W2953037600 cites W2512187837 @default.
• W2953037600 cites W2558161797 @default.
• W2953037600 cites W2613860781 @default.
• W2953037600 cites W2734702700 @default.
• W2953037600 cites W2738238094 @default.
• W2953037600 cites W2763734326 @default.
• W2953037600 cites W2770778494 @default.
• W2953037600 cites W2791318510 @default.
• W2953037600 cites W2806917274 @default.
• W2953037600 cites W2807007486 @default.
• W2953037600 cites W2885026200 @default.
• W2953037600 cites W2893189752 @default.
• W2953037600 cites W2920040309 @default.
• W2953037600 cites W2953206908 @default.
• W2953037600 cites W4242614154 @default.
• W2953037600 doi "https://doi.org/10.1016/j.bbabio.2019.05.004" @default.
• W2953037600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31173729" @default.
• W2953037600 hasPublicationYear "2019" @default.
• W2953037600 type Work @default.
• W2953037600 sameAs 2953037600 @default.
• W2953037600 citedByCount "34" @default.
• W2953037600 countsByYear W29530376002019 @default.
• W2953037600 countsByYear W29530376002020 @default.
• W2953037600 countsByYear W29530376002021 @default.
• W2953037600 countsByYear W29530376002022 @default.
• W2953037600 countsByYear W29530376002023 @default.
• W2953037600 crossrefType "journal-article" @default.
• W2953037600 hasAuthorship W2953037600A5002609699 @default.
• W2953037600 hasAuthorship W2953037600A5072664409 @default.
• W2953037600 hasBestOaLocation W29530376001 @default.
• W2953037600 hasConcept C107824862 @default.
• W2953037600 hasConcept C118792377 @default.
• W2953037600 hasConcept C121332964 @default.
• W2953037600 hasConcept C123669783 @default.
• W2953037600 hasConcept C12554922 @default.
• W2953037600 hasConcept C147597530 @default.
• W2953037600 hasConcept C15920480 @default.
• W2953037600 hasConcept C161790260 @default.
• W2953037600 hasConcept C178790620 @default.
• W2953037600 hasConcept C185544564 @default.

• next