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• W2953040549 endingPage "91" @default.
• W2953040549 startingPage "91" @default.
• W2953040549 abstract "Ginger (Zingiber officinale) was reported to have an antioxidant, antidiabetic effect. This study was done to investigate its therapeutic effect against functional and structural alteration in liver of diabetic rat (intraperitoneal streptozotocin (STZ) in a dose of 60 mg/kg/bw). Thirty adult male rats (three-months-old and 250 g weight) were sorted into five groups (N=6). G1 used as control, G2 was diabetic rats without any treatment, G3 was diabetic rats given oral ginger in a dose of 500 mg/kg/bw, G4 was diabetic rats treated with metformin (500 mg/kg/bw) while G5 received ginger orally. The experiment lasts for six weeks, animals were anesthetized by ether, body weight was recorded for all animals. Blood was collected for further analysis of lipid profile, liver enzymes and total antioxidant. Liver was dissected, weighted and samples were processed for histopathological study. The results showed significant decrease of glaucous level and liver enzymes in ginger treated rats. Total antioxidant was preserved. Ginger lowered blood glucose, level, regained body weight and liver index to near normal values. Diabetes induced degenerative changes and micro-vesicular lipid deposition in hepatocytes with moderate portal area fibrosis. Ultrastructure study confirmed such changes beside demonstrating increased lipid deposition in fat storing cells. Ginger was found to ameliorate those changes in treated animals. Results were matching metformin effects. In conclusion, Ginger as a natural safe Herbal medication can be used to support liver functions in diabetic status." @default.
• W2953040549 created "2019-06-27" @default.
• W2953040549 creator A5016024527 @default.
• W2953040549 date "2019-01-01" @default.
• W2953040549 modified "2023-10-13" @default.
• W2953040549 title "Efficacy of Ginger (Zingiber officinale) in ameliorating streptozotocin-induced diabetic liver injury in rats: Histological and biochemical studies" @default.
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• W2953040549 doi "https://doi.org/10.4103/jmau.jmau_16_19" @default.
• W2953040549 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6585475" @default.
• W2953040549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31293891" @default.
• W2953040549 hasPublicationYear "2019" @default.
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