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• W2953057156 abstract "The chemical synthesis of two phosphono analogues of d-galactofuranosyl phosphate was performed. The natural phosphate seemed to be too labile to allow the chemical synthesis of UDP-Galf, these C-galactofuranosides are stable pharmacophores, and the α-phosphono analogue has been easily converted into UDP-C-Galf. UDP-C-Galf was tested as a competitive inhibitor of UDP-galactopyranose mutase and showed inhibition of Galf formation. Thus, it is of potential interest as an antimycobacterial agent; as an active molecule against Trypanosoma cruzi, the causative agent of South American trypanosomiasis (Chagas' disease), and as a stable analogue for use in UDP-galactopyranose mutase crystallization studies." @default.
• W2953057156 created "2019-06-27" @default.
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• W2953057156 date "1999-07-30" @default.
• W2953057156 modified "2023-10-17" @default.
• W2953057156 title "<scp>d</scp>-Galactofuranosylphosphonates. First Synthesis of UDP-<i>C</i>-<scp>d</scp>-galactofuranose" @default.
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• W2953057156 doi "https://doi.org/10.1021/jo990196p" @default.
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