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- W2953088425 abstract "The two pairs of enantiomers of isoxazolidin-3-ones 3 and 4 were synthesized by means of Lipase PS-catalyzed hydrolyses of suitable racemic butyrates. The same butyrates were also employed as key intermediates in the preparation of racemic 3 and 4. The antimuscarinic potency of the new compounds was assayed in two in vitro functional tests. The eutomers (-)-3 and (-)-4 share the same stereochemistry (5R) of the most potent enantiomer of azamuscarone 2, a structurally related muscarinic agonist. Such a spatial arrangement around the chiral center of 2-4, coupled with the low values of eudismic ratio, represents an anomaly among the chiral muscarinic ligands. This anomaly was accounted for by the absence of a chiral center at C-2, a position whose configuration is crucial in determining the high enantioselectivity of muscarinic agonists and antagonists." @default.
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- W2953088425 date "1995-01-01" @default.
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- W2953088425 title "Synthesis and pharmacological investigation of new chiral muscarinic antagonists." @default.
- W2953088425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7702717" @default.
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