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- W2953102477 abstract "A number of retinoid-related compounds represent classes of antioxidative and proapoptotic agents with promising potential in the treatment of neoplastic diseases. Indeed, the synthetic retinoid amide fenretinide [N-(4-hydroxyphenyl)retinamide] induces apoptosis of cancer cells and acts as a chemotherapeutic drug in cancer therapy. In the present work, and as a continuation of our studies on retinoid-type compounds, the synthesis of melatonin retinamide derivatives was studied as a novel series of melatonin retinoids, using the condensation reaction sequence involving tetrahydrotetramethylnaphthalene carboxylic acid and appropriate melatonin-type moieties. Despite of the weak DPPH inhibition activity pattern of the synthesized compounds, some of them showed a strong inhibition on lipid peroxidation (IVa–b, Va, and VIIa–c, 88, 96, 90, 94, 93, and 86%, respectively at 10–4 M concentration) when melatonin (85% at 10–4 M concentration) was used as a reference compound." @default.
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- W2953102477 date "2006-04-01" @default.
- W2953102477 modified "2023-09-26" @default.
- W2953102477 title "Synthesis and Antioxidant Activity of New Tetrahydro-Naphthalene-Indole Derivatives as Retinoid and Melatonin Analogs" @default.
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- W2953102477 doi "https://doi.org/10.1002/ardp.200500177" @default.
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