FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953102671> ?p ?o ?g. }

• W2953102671 abstract "Coarse-grained molecular simulation models can provide significant insight into the complex behavior of protein systems, but suffer from an inherently distorted description of dynamical properties. We recently demonstrated that, for a heptapeptide of alanine residues, the structural and kinetic properties of a simulation model are linked in a rather simple way, given a certain level of physics present in the model. In this work, we extend these findings to a longer peptide, for which the representation of configuration space in terms of a full enumeration of sequences of helical/coil states along the peptide backbone is impractical. We verify the structural-kinetic relationships by scanning the parameter space of a simple native-biased model and then employ a distinct transferable model to validate and generalize the conclusions. Our results further demonstrate the validity of the previous findings, while clarifying the role of conformational entropy in the determination of the structural-kinetic relationships. More specifically, while the global, long timescale kinetic properties of a particular class of models with varying energetic parameters but approximately fixed conformational entropy are determined by the overarching structural features of the ensemble, a shift in these kinetic observables occurs for models with a distinct representation of steric interactions. At the same time, the relationship between structure and more local, faster kinetic properties is not affected by varying the conformational entropy of the model." @default.
• W2953102671 created "2019-06-27" @default.
• W2953102671 creator A5002664162 @default.
• W2953102671 creator A5005535171 @default.
• W2953102671 date "2017-12-21" @default.
• W2953102671 modified "2023-09-23" @default.
• W2953102671 title "The role of conformational entropy in the determination of structural-kinetic relationships for helix-coil transitions" @default.
• W2953102671 cites W1845618662 @default.
• W2953102671 cites W1964556356 @default.
• W2953102671 cites W1966078827 @default.
• W2953102671 cites W1967333579 @default.
• W2953102671 cites W1973060931 @default.
• W2953102671 cites W1992898397 @default.
• W2953102671 cites W2005864112 @default.
• W2953102671 cites W2012220598 @default.
• W2953102671 cites W2014095962 @default.
• W2953102671 cites W2017562024 @default.
• W2953102671 cites W2023921624 @default.
• W2953102671 cites W2039569314 @default.
• W2953102671 cites W2043793450 @default.
• W2953102671 cites W2044201287 @default.
• W2953102671 cites W2044882887 @default.
• W2953102671 cites W2045332616 @default.
• W2953102671 cites W2062389381 @default.
• W2953102671 cites W2062629061 @default.
• W2953102671 cites W2080845527 @default.
• W2953102671 cites W2085142174 @default.
• W2953102671 cites W2085213650 @default.
• W2953102671 cites W2109924599 @default.
• W2953102671 cites W2144288821 @default.
• W2953102671 cites W2161411241 @default.
• W2953102671 cites W2161731099 @default.
• W2953102671 cites W2163987934 @default.
• W2953102671 cites W2170665034 @default.
• W2953102671 cites W2226825552 @default.
• W2953102671 cites W2240092441 @default.
• W2953102671 cites W2261031917 @default.
• W2953102671 cites W2313374938 @default.
• W2953102671 cites W2326384661 @default.
• W2953102671 cites W2334841042 @default.
• W2953102671 cites W2413334978 @default.
• W2953102671 cites W2467323641 @default.
• W2953102671 cites W2559637536 @default.
• W2953102671 cites W3100013967 @default.
• W2953102671 cites W3100810942 @default.
• W2953102671 cites W585413800 @default.
• W2953102671 doi "https://doi.org/10.1101/237875" @default.
• W2953102671 hasPublicationYear "2017" @default.
• W2953102671 type Work @default.
• W2953102671 sameAs 2953102671 @default.
• W2953102671 citedByCount "0" @default.
• W2953102671 crossrefType "posted-content" @default.
• W2953102671 hasAuthorship W2953102671A5002664162 @default.
• W2953102671 hasAuthorship W2953102671A5005535171 @default.
• W2953102671 hasBestOaLocation W29531026711 @default.
• W2953102671 hasConcept C106301342 @default.
• W2953102671 hasConcept C121332964 @default.
• W2953102671 hasConcept C121864883 @default.
• W2953102671 hasConcept C135889238 @default.
• W2953102671 hasConcept C147597530 @default.
• W2953102671 hasConcept C17744445 @default.
• W2953102671 hasConcept C185592680 @default.
• W2953102671 hasConcept C186060115 @default.
• W2953102671 hasConcept C199539241 @default.
• W2953102671 hasConcept C201194858 @default.
• W2953102671 hasConcept C2776359362 @default.
• W2953102671 hasConcept C32848918 @default.
• W2953102671 hasConcept C32909587 @default.
• W2953102671 hasConcept C59593255 @default.
• W2953102671 hasConcept C62520636 @default.
• W2953102671 hasConcept C69308434 @default.
• W2953102671 hasConcept C71240020 @default.
• W2953102671 hasConcept C74650414 @default.
• W2953102671 hasConcept C86803240 @default.
• W2953102671 hasConcept C94625758 @default.
• W2953102671 hasConcept C97355855 @default.
• W2953102671 hasConceptScore W2953102671C106301342 @default.
• W2953102671 hasConceptScore W2953102671C121332964 @default.
• W2953102671 hasConceptScore W2953102671C121864883 @default.
• W2953102671 hasConceptScore W2953102671C135889238 @default.
• W2953102671 hasConceptScore W2953102671C147597530 @default.
• W2953102671 hasConceptScore W2953102671C17744445 @default.
• W2953102671 hasConceptScore W2953102671C185592680 @default.
• W2953102671 hasConceptScore W2953102671C186060115 @default.
• W2953102671 hasConceptScore W2953102671C199539241 @default.
• W2953102671 hasConceptScore W2953102671C201194858 @default.
• W2953102671 hasConceptScore W2953102671C2776359362 @default.
• W2953102671 hasConceptScore W2953102671C32848918 @default.
• W2953102671 hasConceptScore W2953102671C32909587 @default.
• W2953102671 hasConceptScore W2953102671C59593255 @default.
• W2953102671 hasConceptScore W2953102671C62520636 @default.
• W2953102671 hasConceptScore W2953102671C69308434 @default.
• W2953102671 hasConceptScore W2953102671C71240020 @default.
• W2953102671 hasConceptScore W2953102671C74650414 @default.
• W2953102671 hasConceptScore W2953102671C86803240 @default.
• W2953102671 hasConceptScore W2953102671C94625758 @default.
• W2953102671 hasConceptScore W2953102671C97355855 @default.
• W2953102671 hasLocation W29531026711 @default.
• W2953102671 hasLocation W29531026712 @default.
• W2953102671 hasLocation W29531026713 @default.

• next