Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953103636> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2953103636 endingPage "e202" @default.
- W2953103636 startingPage "e202" @default.
- W2953103636 abstract "Objective: Angiotensin II in the failing heart initially helps to maintain cardiac output and blood pressure, but ultimately accelerates its deterioration. In this study, we established an arrhythmia-induced heart failure (HF) model in zebrafish and investigated the role of renin-angiotensin-aldosterone system (RAAS) modulation using an angiotensin II type 1 receptor blocker, fimasartan, by assessing cellular and physiologic responses as well as morbidity and mortality. Design and method: HF was induced by exposure to 20 μM terfenadine in zebrafish larvae. Morphologic, physiologic, and functional parameters were assessed with or without fimasartan pretreatment. Results: Zebrafish exposed to terfenadine showed marked dilation of the ventricle and reduction in systolic function. Treatment with terfenadine was associated with a ten-fold higher expression of atrial natriuretic peptide (p < 0.01 vs. vehicle), increased p53 mRNA expression and chromatin fragmentation by TUNEL assay, all of which were significantly reduced with fimasartan treatment. Moreover, fimasartan improved fractional shortening (FS) (terfenadine + fimasartan 21.7 ± 2.1 % vs. terfenadine + vehicle 8.4 ± 0.7 % vs. vehicle 37.3 ± 2.1 %, p < 0.01). Finally, treatment with fimasartan remarkably reduced mortality (terfenadine + fimasartan 36.0% vs. terfenadine 96.0%, p < 0.01). Conclusions: Fimasartan effectively prevented HF and improved survival in zebrafish. Reduction of apoptotic cell death and improved hemodynamics might be the mechanisms behind these effects. Further human studies are warranted to evaluate the possible role of fimasartan in heart failure treatment." @default.
- W2953103636 created "2019-06-27" @default.
- W2953103636 creator A5005773915 @default.
- W2953103636 creator A5017768100 @default.
- W2953103636 creator A5060951283 @default.
- W2953103636 creator A5067900740 @default.
- W2953103636 date "2019-07-01" @default.
- W2953103636 modified "2023-09-25" @default.
- W2953103636 title "FIMASARTAN, AN ANGIOTENSIN II RECEPTOR ANTAGONIST, AMELIORATES AN IN VIVO ZEBRAFISH MODEL OF HEART FAILURE" @default.
- W2953103636 doi "https://doi.org/10.1097/01.hjh.0000572612.43882.47" @default.
- W2953103636 hasPublicationYear "2019" @default.
- W2953103636 type Work @default.
- W2953103636 sameAs 2953103636 @default.
- W2953103636 citedByCount "0" @default.
- W2953103636 crossrefType "journal-article" @default.
- W2953103636 hasAuthorship W2953103636A5005773915 @default.
- W2953103636 hasAuthorship W2953103636A5017768100 @default.
- W2953103636 hasAuthorship W2953103636A5060951283 @default.
- W2953103636 hasAuthorship W2953103636A5067900740 @default.
- W2953103636 hasBestOaLocation W29531036361 @default.
- W2953103636 hasConcept C104317684 @default.
- W2953103636 hasConcept C126322002 @default.
- W2953103636 hasConcept C134018914 @default.
- W2953103636 hasConcept C2776878037 @default.
- W2953103636 hasConcept C2778198053 @default.
- W2953103636 hasConcept C2779303165 @default.
- W2953103636 hasConcept C2908929049 @default.
- W2953103636 hasConcept C55493867 @default.
- W2953103636 hasConcept C71924100 @default.
- W2953103636 hasConcept C84393581 @default.
- W2953103636 hasConcept C86803240 @default.
- W2953103636 hasConcept C98274493 @default.
- W2953103636 hasConceptScore W2953103636C104317684 @default.
- W2953103636 hasConceptScore W2953103636C126322002 @default.
- W2953103636 hasConceptScore W2953103636C134018914 @default.
- W2953103636 hasConceptScore W2953103636C2776878037 @default.
- W2953103636 hasConceptScore W2953103636C2778198053 @default.
- W2953103636 hasConceptScore W2953103636C2779303165 @default.
- W2953103636 hasConceptScore W2953103636C2908929049 @default.
- W2953103636 hasConceptScore W2953103636C55493867 @default.
- W2953103636 hasConceptScore W2953103636C71924100 @default.
- W2953103636 hasConceptScore W2953103636C84393581 @default.
- W2953103636 hasConceptScore W2953103636C86803240 @default.
- W2953103636 hasConceptScore W2953103636C98274493 @default.
- W2953103636 hasLocation W29531036361 @default.
- W2953103636 hasLocation W29531036362 @default.
- W2953103636 hasOpenAccess W2953103636 @default.
- W2953103636 hasPrimaryLocation W29531036361 @default.
- W2953103636 hasRelatedWork W1991657120 @default.
- W2953103636 hasRelatedWork W1992220075 @default.
- W2953103636 hasRelatedWork W2020571025 @default.
- W2953103636 hasRelatedWork W2024736606 @default.
- W2953103636 hasRelatedWork W2047925791 @default.
- W2953103636 hasRelatedWork W2076343727 @default.
- W2953103636 hasRelatedWork W2077960701 @default.
- W2953103636 hasRelatedWork W2091193686 @default.
- W2953103636 hasRelatedWork W2116962665 @default.
- W2953103636 hasRelatedWork W2151139437 @default.
- W2953103636 hasVolume "37" @default.
- W2953103636 isParatext "false" @default.
- W2953103636 isRetracted "false" @default.
- W2953103636 magId "2953103636" @default.
- W2953103636 workType "article" @default.