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- W2953104417 abstract "A novel series of 1-aryl-4,5,6,7-tetrahydro-1H-indazole-5-carboxylic acids and 2-aryl-4,5,6,7-tetrahydro-2H-indazole-5-carboxylic acids were synthesized via condensation between a phenylhydrazine and a 2-(hydroxymethylene)cyclohexanone-4-carboxylate, and the antiinflammatory activity was determined. In the carrageenan edema test, 1-aryl-4,5,6,7-tetrahydro-1H-indazole-5-carboxylic acids exhibited fairly high antiinflammatory activity. However, the 2-aryl isomers were far less active than the former. The most active compound of the series was 1-phenyl-4,5,6,7-tetrahydro-1H-indazole-5-carboxylic acid, which had an ED50 value of 3.5 mg/kg." @default.
- W2953104417 created "2019-06-27" @default.
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- W2953104417 date "1979-05-22" @default.
- W2953104417 modified "2023-09-26" @default.
- W2953104417 title "ChemInform Abstract: SYNTHESES AND ANTIINFLAMMATORY ACTIONS OF 4,5,6,7-TETRAHYDROINDAZOLE-5-CARBOXYLIC ACIDS" @default.
- W2953104417 cites W1981250311 @default.
- W2953104417 doi "https://doi.org/10.1002/chin.197921237" @default.
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