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• W2953113365 abstract "Abstract Asthma is a common, under-diagnosed disease affecting all ages. We sought to identify a nasal brush-based classifier of mild/moderate asthma. 190 subjects with mild/moderate asthma and controls underwent nasal brushing and RNA sequencing of nasal samples. A machine learning-based pipeline identified an asthma classifier consisting of 90 genes interpreted via an L2-regularized logistic regression classification model. This classifier performed with strong predictive value and sensitivity across eight test sets, including (1) a test set of independent asthmatic and control subjects profiled by RNA sequencing (positive and negative predictive values of 1.00 and 0.96, respectively; AUC of 0.994), (2) two independent case-control cohorts of asthma profiled by microarray, and (3) five cohorts with other respiratory conditions (allergic rhinitis, upper respiratory infection, cystic fibrosis, smoking), where the classifier had a low to zero misclassification rate. Following validation in large, prospective cohorts, this classifier could be developed into a nasal biomarker of asthma." @default.
• W2953113365 created "2019-06-27" @default.
• W2953113365 creator A5001033968 @default.
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• W2953113365 date "2018-06-11" @default.
• W2953113365 modified "2023-10-16" @default.
• W2953113365 title "A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data" @default.
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• W2953113365 doi "https://doi.org/10.1038/s41598-018-27189-4" @default.
• W2953113365 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5995932" @default.
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