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- W2953118625 abstract "Mitomycins make up a group of antitumor natural products that are biosynthesized from aminohydroxybenzoic acid (AHBA) and N-acetylglucosamine (GlcNAc). While the biosynthetic gene cluster was reported two decades ago, the mechanism by which the two building blocks, AHBA and GlcNAc, are coupled during biosynthesis remained uncharacterized. Here we report evidence that AHBA is first loaded onto an MmcB acyl carrier protein (ACP) by a MitE acyl ACP synthetase, followed by a transfer of GlcNAc from UDP-GlcNAc by MitB. The results suggest that the early steps of mitomycin biosynthesis proceed via intermediates linked to MmcB." @default.
- W2953118625 created "2019-06-27" @default.
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- W2953118625 date "2019-06-07" @default.
- W2953118625 modified "2023-10-13" @default.
- W2953118625 title "Characterization of Acyl Carrier Protein-Dependent Glycosyltransferase in Mitomycin C Biosynthesis" @default.
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- W2953118625 doi "https://doi.org/10.1021/acs.biochem.9b00379" @default.
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