Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953120516> ?p ?o ?g. }
- W2953120516 endingPage "598" @default.
- W2953120516 startingPage "587" @default.
- W2953120516 abstract "Abstract Background Nlrp6 is a nucleotide-binding oligomerization domain-like receptor (NLR) that forms atypical inflammasomes. Nlrp6 modulates the gut epithelium interaction with the microbiota. However, the expression and function of Nlrp6 in the kidney, a sterile environment, have not been characterized. We explored the role of Nlrp6 in acute kidney injury (AKI). Methods In a transcriptomics array of murine nephrotoxic AKI, Nlrp6 and Naip3 were the only significantly downregulated NLR genes. The functional implications of Nlrp6 downregulation were explored in mice and in cultured murine tubular cells. Results Nlrp6 was expressed by healthy murine and human kidney tubular epithelium, and expression was reduced during human kidney injury or murine nephrotoxic AKI induced by cisplatin or a folic acid overdose. Genetic Nlrp6 deficiency resulted in upregulation of kidney extracellular signal–regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) phosphorylation and more severe AKI and kidney inflammation. In cultured tubular cells, Nlrp6 downregulation induced by specific small interfering RNA resulted in upregulation of ERK1/2 and p38 phosphorylation and chemokine messenger RNA expression and downregulation of the nephroprotective gene Klotho. MAPK inhibition prevented the inflammatory response in Nlrp6-deficient cells. Conclusion Nlrp6 dampens sterile inflammation and has a nephroprotective role during nephrotoxic kidney injury through suppression of MAP kinase activation." @default.
- W2953120516 created "2019-06-27" @default.
- W2953120516 creator A5022080798 @default.
- W2953120516 creator A5034004674 @default.
- W2953120516 creator A5040117830 @default.
- W2953120516 creator A5045038056 @default.
- W2953120516 creator A5063245254 @default.
- W2953120516 date "2019-08-29" @default.
- W2953120516 modified "2023-10-17" @default.
- W2953120516 title "Loss of NLRP6 expression increases the severity of acute kidney injury" @default.
- W2953120516 cites W1529674879 @default.
- W2953120516 cites W1864661279 @default.
- W2953120516 cites W1965256404 @default.
- W2953120516 cites W1972745528 @default.
- W2953120516 cites W1989560133 @default.
- W2953120516 cites W2004497370 @default.
- W2953120516 cites W2005242977 @default.
- W2953120516 cites W2010571189 @default.
- W2953120516 cites W2015730823 @default.
- W2953120516 cites W2025905713 @default.
- W2953120516 cites W2027732533 @default.
- W2953120516 cites W2028288361 @default.
- W2953120516 cites W2029354317 @default.
- W2953120516 cites W2036786349 @default.
- W2953120516 cites W2041850473 @default.
- W2953120516 cites W2044147293 @default.
- W2953120516 cites W2044804580 @default.
- W2953120516 cites W2050449334 @default.
- W2953120516 cites W2052708139 @default.
- W2953120516 cites W2060778210 @default.
- W2953120516 cites W2080717362 @default.
- W2953120516 cites W2088960649 @default.
- W2953120516 cites W2100048287 @default.
- W2953120516 cites W2100736582 @default.
- W2953120516 cites W2102244214 @default.
- W2953120516 cites W2105356199 @default.
- W2953120516 cites W2106855445 @default.
- W2953120516 cites W2122299571 @default.
- W2953120516 cites W2124285670 @default.
- W2953120516 cites W2132754300 @default.
- W2953120516 cites W2134735862 @default.
- W2953120516 cites W2134931198 @default.
- W2953120516 cites W2135800410 @default.
- W2953120516 cites W2135835434 @default.
- W2953120516 cites W2141869612 @default.
- W2953120516 cites W2143763048 @default.
- W2953120516 cites W2146081758 @default.
- W2953120516 cites W2150401175 @default.
- W2953120516 cites W2151713498 @default.
- W2953120516 cites W2161171014 @default.
- W2953120516 cites W2167927725 @default.
- W2953120516 cites W2172184476 @default.
- W2953120516 cites W2187762512 @default.
- W2953120516 cites W2188593832 @default.
- W2953120516 cites W2229792859 @default.
- W2953120516 cites W2276967039 @default.
- W2953120516 cites W2462023038 @default.
- W2953120516 cites W2470889344 @default.
- W2953120516 cites W2519048082 @default.
- W2953120516 cites W2528178304 @default.
- W2953120516 cites W2588195614 @default.
- W2953120516 cites W2614986146 @default.
- W2953120516 cites W2624514227 @default.
- W2953120516 cites W2742175177 @default.
- W2953120516 cites W2748843269 @default.
- W2953120516 cites W2770108610 @default.
- W2953120516 cites W2781320385 @default.
- W2953120516 cites W2801703343 @default.
- W2953120516 cites W2868695026 @default.
- W2953120516 cites W2904420738 @default.
- W2953120516 cites W2920099273 @default.
- W2953120516 cites W4229508150 @default.
- W2953120516 doi "https://doi.org/10.1093/ndt/gfz169" @default.
- W2953120516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31504777" @default.
- W2953120516 hasPublicationYear "2019" @default.
- W2953120516 type Work @default.
- W2953120516 sameAs 2953120516 @default.
- W2953120516 citedByCount "23" @default.
- W2953120516 countsByYear W29531205162020 @default.
- W2953120516 countsByYear W29531205162021 @default.
- W2953120516 countsByYear W29531205162022 @default.
- W2953120516 countsByYear W29531205162023 @default.
- W2953120516 crossrefType "journal-article" @default.
- W2953120516 hasAuthorship W2953120516A5022080798 @default.
- W2953120516 hasAuthorship W2953120516A5034004674 @default.
- W2953120516 hasAuthorship W2953120516A5040117830 @default.
- W2953120516 hasAuthorship W2953120516A5045038056 @default.
- W2953120516 hasAuthorship W2953120516A5063245254 @default.
- W2953120516 hasConcept C104317684 @default.
- W2953120516 hasConcept C126189478 @default.
- W2953120516 hasConcept C126322002 @default.
- W2953120516 hasConcept C127561419 @default.
- W2953120516 hasConcept C153911025 @default.
- W2953120516 hasConcept C184235292 @default.
- W2953120516 hasConcept C2780091579 @default.
- W2953120516 hasConcept C2780472472 @default.
- W2953120516 hasConcept C502942594 @default.
- W2953120516 hasConcept C51551487 @default.