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• W2953123040 abstract "ABSTRACT Whether common principles regulate the self-renewing potential of neural stem cells (NSCs) throughout the developing central nervous system is still unclear. In the Drosophila ventral nerve cord and central brain, asymmetrically dividing NSCs, called neuroblasts (NBs), progress through a series of sequentially expressed transcription factors that limits self-renewal by silencing a genetic module involving the transcription factor Chinmo. Here, we find that Chinmo also promotes neuroepithelium growth in the optic lobe during early larval stages by boosting symmetric self-renewing divisions while preventing differentiation. Neuroepithelium differentiation in late larvae requires the transcriptional silencing of chinmo by ecdysone, the main steroid hormone, therefore allowing coordination of NSC self-renewal with organismal growth. In contrast, chinmo silencing in NBs is post-transcriptional and does not require ecdysone. Thus, during Drosophila development, humoral cues or tissue-intrinsic temporal specification programs respectively limit self-renewal in different types of neural progenitors through the transcriptional and post-transcriptional regulation of the same transcription factor. SUMMARY STATEMENT Here, we demonstrate that the transcription factor chinmo acts as a master gene of NSC self-renewal in the different regions of the developing Drosophila brain where it is controlled by distinct regulatory strategies." @default.
• W2953123040 created "2019-06-27" @default.
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• W2953123040 date "2017-10-20" @default.
• W2953123040 modified "2023-10-11" @default.
• W2953123040 title "Two distinct mechanisms silence<i>chinmo</i>in<i>Drosophila</i>neuroblasts and neuroepithelial cells to limit their self-renewal" @default.
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• W2953123040 doi "https://doi.org/10.1101/206060" @default.
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