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- W2953129643 abstract "Abstract Five novel 4-phenylquinazolinols were synthesised in three steps. Their application as ligands in the titanium tetraisopropoxide promoted catalytic enantioselective addition of phenylacetylene to a variety of aldehydes gave propargylic alcohols. Under the optimised reaction conditions, the best enantioselectivity was obtained using l -lactic acid derived 4-phenylquinazolinol and apart from the cyclohexylcarbaldehyde derivative, 16 propargylic alcohols were then synthesised in moderate to excellent enantiomeric excess from 53% to 97%." @default.
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- W2953129643 date "2014-11-01" @default.
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- W2953129643 title "Synthesis of quinazoline based chiral ligands and application in the enantioselective addition of phenylacetylene to aldehydes" @default.
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- W2953129643 doi "https://doi.org/10.1016/j.tet.2014.08.067" @default.
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