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- W2953131129 abstract "Alzheimer's disease (AD) is the most common neurodegenerative disease and is characterized by neurodegeneration and cognitive deficits. Amyloid beta (Aβ) peptide is known to be a major cause of AD pathogenesis. However, recent studies have clarified that mitochondrial deficiency is also a mediator or trigger for AD development. Interestingly, red ginseng (RG) has been demonstrated to have beneficial effects on AD pathology. However, there is no evidence showing whether RG extract (RGE) can inhibit the mitochondrial deficit-mediated pathology in the experimental models of AD. The effects of RGE on Aβ-mediated mitochondrial deficiency were investigated in both HT22 mouse hippocampal neuronal cells and the brains of 5XFAD Aβ-overexpressing transgenic mice. To examine whether RGE can affect mitochondria-related pathology, we used immunohistostaining to study the effects of RGE on Aβ accumulation, neuroinflammation, neurodegeneration, and impaired adult hippocampal neurogenesis in hippocampal formation of 5XFAD mice. In vitro and in vivo findings indicated that RGE significantly improves Aβ-induced mitochondrial pathology. In addition, RGE significantly ameliorated AD-related pathology, such as Aβ deposition, gliosis, and neuronal loss, and deficits in adult hippocampal neurogenesis in brains with AD. Our results suggest that RGE may be a mitochondria-targeting agent for the treatment of AD." @default.
- W2953131129 created "2019-06-27" @default.
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- W2953131129 date "2019-06-21" @default.
- W2953131129 modified "2023-10-13" @default.
- W2953131129 title "Red Ginseng Attenuates Aβ-Induced Mitochondrial Dysfunction and Aβ-mediated Pathology in an Animal Model of Alzheimer’s Disease" @default.
- W2953131129 cites W1151450738 @default.
- W2953131129 cites W1416410314 @default.
- W2953131129 cites W1496906377 @default.
- W2953131129 cites W1503983308 @default.
- W2953131129 cites W1539544057 @default.
- W2953131129 cites W1574091123 @default.
- W2953131129 cites W1578593546 @default.
- W2953131129 cites W1616471316 @default.
- W2953131129 cites W1812789667 @default.
- W2953131129 cites W1968900405 @default.
- W2953131129 cites W1972960028 @default.
- W2953131129 cites W1974851337 @default.
- W2953131129 cites W1981630887 @default.
- W2953131129 cites W1985840892 @default.
- W2953131129 cites W1994050829 @default.
- W2953131129 cites W1994451431 @default.
- W2953131129 cites W2001296110 @default.
- W2953131129 cites W2003466445 @default.
- W2953131129 cites W2007047564 @default.
- W2953131129 cites W2018239217 @default.
- W2953131129 cites W2018659142 @default.
- W2953131129 cites W2026393786 @default.
- W2953131129 cites W2030447195 @default.
- W2953131129 cites W2031837176 @default.
- W2953131129 cites W2033736939 @default.
- W2953131129 cites W2033863809 @default.
- W2953131129 cites W2035594496 @default.
- W2953131129 cites W2044911918 @default.
- W2953131129 cites W2045196111 @default.
- W2953131129 cites W2053170805 @default.
- W2953131129 cites W2055129301 @default.
- W2953131129 cites W2057528026 @default.
- W2953131129 cites W2071736940 @default.
- W2953131129 cites W2075536570 @default.
- W2953131129 cites W2080154605 @default.
- W2953131129 cites W2080718047 @default.
- W2953131129 cites W2087255758 @default.
- W2953131129 cites W2089141103 @default.
- W2953131129 cites W2089223747 @default.
- W2953131129 cites W2100734309 @default.
- W2953131129 cites W2103251946 @default.
- W2953131129 cites W2113729748 @default.
- W2953131129 cites W2113742859 @default.
- W2953131129 cites W2116784956 @default.
- W2953131129 cites W2123080558 @default.
- W2953131129 cites W2124693206 @default.
- W2953131129 cites W2127417764 @default.
- W2953131129 cites W2129899796 @default.
- W2953131129 cites W2141594388 @default.
- W2953131129 cites W2145796722 @default.
- W2953131129 cites W2146073155 @default.
- W2953131129 cites W2146249493 @default.
- W2953131129 cites W2146316688 @default.
- W2953131129 cites W2146594405 @default.
- W2953131129 cites W2147051256 @default.
- W2953131129 cites W2152165298 @default.
- W2953131129 cites W2153533547 @default.
- W2953131129 cites W2154345609 @default.
- W2953131129 cites W2155868889 @default.
- W2953131129 cites W2165474925 @default.
- W2953131129 cites W2170644095 @default.
- W2953131129 cites W2171542141 @default.
- W2953131129 cites W2290984097 @default.
- W2953131129 cites W2298887234 @default.
- W2953131129 cites W2299614790 @default.
- W2953131129 cites W2303236646 @default.
- W2953131129 cites W2414294110 @default.
- W2953131129 cites W2461815383 @default.
- W2953131129 cites W2503742514 @default.
- W2953131129 cites W2546627707 @default.
- W2953131129 cites W2555009750 @default.
- W2953131129 cites W2579940969 @default.
- W2953131129 cites W2590437553 @default.
- W2953131129 cites W2593049851 @default.