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- W2953146931 endingPage "346" @default.
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- W2953146931 abstract "The chimeric antigen receptor T cell (CAR-T cell) immunotherapy currently represents a hot research trend and it is expected to revolutionize the field of cancer therapy. Promising outcomes have been achieved using CAR-T cell therapy for haematological malignancies. Despite encouraging results, several challenges still pose eminent hurdles before being fully recognized. Directing CAR-T cells to target a single tumour associated antigen (TAA) as the case in haematological malignancies might be much simpler than targeting the extensive inhibitory microenvironments associated with solid tumours. This review focuses on the basic principles involved in development of CAR-T cells, emphasizing the differences between humoral IgG, T-cell receptors, CAR and Fcγ-CR constructs. It also highlights the complex inhibitory network that is usually associated with solid tumours, and tackles recent advances in the clinical studies that have provided great hope for the future use of CAR-T cell immunotherapy. While current Fcγ-CR T cell immunotherapy is in pre-clinical stage, is expected to provide a sound therapeutic approach to add to existing classical chemo- and radio-therapeutic modalities." @default.
- W2953146931 created "2019-06-27" @default.
- W2953146931 creator A5023919260 @default.
- W2953146931 creator A5025388120 @default.
- W2953146931 creator A5025969458 @default.
- W2953146931 creator A5033802441 @default.
- W2953146931 creator A5044009112 @default.
- W2953146931 creator A5061253161 @default.
- W2953146931 creator A5069702670 @default.
- W2953146931 creator A5072842070 @default.
- W2953146931 creator A5074406949 @default.
- W2953146931 creator A5076267420 @default.
- W2953146931 creator A5087593263 @default.
- W2953146931 date "2019-08-01" @default.
- W2953146931 modified "2023-10-01" @default.
- W2953146931 title "Recent perspective on CAR and Fcγ-CR T cell immunotherapy for cancers: Preclinical evidence versus clinical outcomes" @default.
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