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• W2953159968 abstract "Abstract Biological functions of micro RNAs (miRNAs) in the early stages of vertebrate development remain largely unknown. In zebrafish, miRNA miR-92a-3p is abundant in the germ cells throughout gonadal development, as well as in ovulated oocytes. Previously, we demonstrated that inhibition of miR-92a-3p in mature ovaries resulted in developmental arrest at the 1-cell stage upon fertilization of the affected oocytes. This suggested functions of miR-92a-3p in early development. In the present study, we identified wee2 , an oocyte-specific protein tyrosine kinase, as a target of maternal miR-92a-3p during the early stages of zebrafish embryogenesis. Spatiotemporal co-presence of both miR-92a-3p and wee2 during early embryo development was confirmed by absolute quantification and in situ hybridization. Targeted knockdown of miR-92a-3p in embryos resulted in retarded embryonic development over the first 24 hours. Target validation assays demonstrated that miR-92a-3p interacted with the predicted wee2 3’UTR binding site, which was strongly suppressed by endogenous miR-92a-3p. Our results suggest that miR-92a-3p regulates the abundance of wee2 , a cyclin-dependent kinase 1 inhibitor, thus having important role in regulation of the cell cycle during cleavage stages in zebrafish. Summary statement In zebrafish, maternal miR-92a-3p was demonstrated to suppress translation of wee2 , a cyclin-dependent kinase 1 inhibitor which regulates cell cycle progression during the early stages of embryogenesis." @default.
• W2953159968 created "2019-06-27" @default.
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• W2953159968 date "2019-06-24" @default.
• W2953159968 modified "2023-09-27" @default.
• W2953159968 title "miR-92a-3p controls cell cycle progression in zebrafish" @default.
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• W2953159968 doi "https://doi.org/10.1101/680991" @default.
• W2953159968 hasPublicationYear "2019" @default.
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