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- W2953161010 endingPage "4204" @default.
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- W2953161010 abstract "2-Nitrophenyl isocyanide is introduced as a convertible isocyanide with demonstration of its feasibility and applicability in an efficient synthesis of the fused γ-lactam β-lactone bicycle of proteasome inhibitor omuralide. Starting from a linear keto acid precursor, the fused γ-lactam β-lactone bicycle was prepared in four steps by a sequential biscyclization strategy; a stereocontrolled Ugi reaction and the concomitant direct β-lactonization following the formation of an N-acylbenzotriazole intermediate. The N-acylbenzotriazole is amenable to intra- or intermolecular attack from a variety of nucleophiles with a catalytic amount of base to form the pyroglutamic acid derivatives." @default.
- W2953161010 created "2019-06-27" @default.
- W2953161010 creator A5027857671 @default.
- W2953161010 creator A5043986012 @default.
- W2953161010 date "2008-05-07" @default.
- W2953161010 modified "2023-10-07" @default.
- W2953161010 title "2-Nitrophenyl Isocyanide as a Versatile Convertible Isocyanide: Rapid Access to a Fused γ-Lactam β-Lactone Bicycle" @default.
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- W2953161010 doi "https://doi.org/10.1021/jo800486k" @default.
- W2953161010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18459807" @default.
- W2953161010 hasPublicationYear "2008" @default.
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