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- W2953168319 abstract "Several 1-alkyl-1,2,3,4-tetrahydroisoquinoline (TIQ) derivatives, which may play a role in Parkinson's disease, have been synthesized via Pummerer-type cyclization of the sulfonium ion formed in situ from N-formyl sulfoxide. Using an in vitro trypan blue exclusion assay, high concentrations of TIQ derivatives possessing bulky alkyl group substituents such as 1-cyclobutyl-, 1-cyclohexyl-, 1-phenyl- or 1-benzyl- at the C-1 position were found to significantly affect the viability of PC12 cells. Moreover, TIQ derivatives that moderately or strongly induced apoptosis (e.g., 1-phenyl-TIQ and 1-cyclohexyl-TIQ, respectively) paralleled the results obtained using the trypan blue exclusion assay. These results suggest that the size and electron-donating properties of functional groups may affect the cytotoxicity of TIQ derivatives." @default.
- W2953168319 created "2019-06-27" @default.
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- W2953168319 date "2006-08-01" @default.
- W2953168319 modified "2023-10-17" @default.
- W2953168319 title "Synthesis and in vitro Cytotoxicity of 1,2,3,4-Tetrahydroisoquinoline Derivatives." @default.
- W2953168319 cites W2097705251 @default.
- W2953168319 doi "https://doi.org/10.1002/chin.200631128" @default.
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