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- W2953194646 abstract "SUMMARY The Structural Maintenance of Chromosomes (SMC) complex plays an important role in chromosome organization and segregation in most living organisms. In Caulobacter crescentus , SMC is required to align the left and the right arms of the chromosome that run in parallel down the long axis of the cell. However, the mechanism of SMC-mediated alignment of chromosomal arms remains elusive. Here, using a genome-wide chromosome conformation capture assay, chromatin immunoprecipitation with deep sequencing, and microscopy of single cells, we show that Caulobacter SMC is recruited to the centromeric parS site and that SMC-mediated arm alignment depends on the chromosome partitioning protein ParB. We provide evidence that SMC likely tethers the parS- proximal regions of the chromosomal arms together, promoting arm alignment. Strikingly, the co-orientation of SMC translocation and the transcription of highly-expressed genes is crucial for the alignment of parS- proximal regions of the chromosomal arms. Highly-transcribed genes near parS that are oriented against SMC translocation disrupt arm alignment suggesting that head-on transcription interferes with SMC translocation. Our results demonstrate a tight interdependence of bacterial chromosome organization and global patterns of transcription." @default.
- W2953194646 created "2019-06-27" @default.
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- W2953194646 date "2017-04-07" @default.
- W2953194646 modified "2023-10-11" @default.
- W2953194646 title "SMC progressively aligns chromosomal arms in Caulobacter crescentus but is antagonized by convergent transcription" @default.
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- W2953194646 doi "https://doi.org/10.1101/125344" @default.
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