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• W2953202972 abstract "Aquilaria crassna Pierre ex Lecomte leaf might be a potential source of natural ingredients for anti-ageing cosmetics. Our study objectives were to assess the variation of the bioactive components i.e. iriflophenone 3,5-C-β-d-diglucoside (1), iriflophenone 3-C-β-d-glucoside (2), mangiferin (3) and genkwanin 5-O-β-primevoside (4) in leaves and other parts of the plants collected from different places in Thailand. The bioactivities beneficial for cosmetic uses of A. crassna leaf extracts were explored. The antioxidant activities of the extracts were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The antiglycation activities were evaluated using a bovine serum albumin-fructose assay, and the anti-inflammatory activities of the extracts were investigated via the inhibition of interleukin-1α (IL-1α), interleukin-8 (IL-8) and prostaglandin E2 (PGE2) secreted from human keratinocyte cells after UVB irradiation. The extracts were also evaluated for nitric oxide (NO) inhibition on lipopolysaccharide-stimulated macrophage cells (RAW 264.7) and lipoxygenase (LOX) inhibition using red ferric thiocyanate assays. The results showed that the young leaves and flowers of A. crassna, contained high total contents of 1–4 of which 3 presented as a major compound. The aqueous and 70% ethanolic extracts of the young leaves showed higher antioxidant activities than that of the mature leaves. The extracts of the young leaves showed antiglycation properties with the half maximal inhibitory concentration (IC50) of 5.21 ± 0.54 μg/mL for the 70% ethanolic extracts, where the aqueous extracts of the young leaves had an IC50 value of 9.00 ± 1.38 μg/mL, while a positive standard, aminoguanidine, showed an IC50 value of 9.69 ± 0.75 μg/mL. The anti-inflammatory activities revealed that the aqueous extracts expressed strong IL-1α and IL-8 inhibitions, while the 70% ethanolic extract showed IL-1α and NO inhibitions. Both extracts did not show inhibitory activity on LOX and PGE2. The results suggest that the extracts of young leaves of A. crassna are promising active ingredients for further application in cosmetic and cosmeceutical industry." @default.
• W2953202972 created "2019-06-27" @default.
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• W2953202972 date "2019-10-01" @default.
• W2953202972 modified "2023-09-30" @default.
• W2953202972 title "Assessment of the bioactive components, antioxidant, antiglycation and anti-inflammatory properties of Aquilaria crassna Pierre ex Lecomte leaves" @default.
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• W2953202972 doi "https://doi.org/10.1016/j.indcrop.2019.06.011" @default.
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