Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953203604> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2953203604 abstract "Abstract As a further part of our chemical and biological studies in this field, we describe the multistep preparations of the properly substituted 2-(1-piperazinyl)chromone 1b , 4-(1-piperazinyl)coumarins 5c – h , their linear benzo-fused analogues 4a , b and 8a , b , bicyclic ( 15e – g ) and tricyclic ( 15h , i ) fused derivatives of 6-(1-piperazinyl)pyrimidin-4(3 H )-one, and of the 4 H -pyrido[1,2- a ]pyrimidine derivatives 9b , c . The in vitro evaluation of their inhibitory properties towards human platelet aggregation induced in platelet-rich plasma by ADP, collagen, or the Ca 2+ ionophore A23187 showed the high activity of compounds 5d – g and 15f , g , i , among which the coumarins 5g and 5d proved to be, in that order, the most effective in vitro antiplatelet agents until now synthesized by us. Thus, in order to consider also the 4-aminocoumarin structural class, we developed a new statistically significant 3-D QSAR model, more general than the one previously obtained, through a further CoMFA study based on the antiplatelet activity data and molecular steric and electrostatic potentials of both the previously studied and herein described compounds." @default.
- W2953203604 created "2019-06-27" @default.
- W2953203604 creator A5001000707 @default.
- W2953203604 creator A5004330222 @default.
- W2953203604 creator A5012291954 @default.
- W2953203604 creator A5028854670 @default.
- W2953203604 creator A5043803761 @default.
- W2953203604 creator A5056030700 @default.
- W2953203604 creator A5087208103 @default.
- W2953203604 date "2003-04-29" @default.
- W2953203604 modified "2023-09-23" @default.
- W2953203604 title "Coumarin, Chromone, and 4(3H)-Pyrimidinone Novel Bicyclic and Tricyclic Derivatives as Antiplatelet Agents: Synthesis, Biological Evaluation, and Comparative Molecular Field Analysis." @default.
- W2953203604 cites W1995680806 @default.
- W2953203604 doi "https://doi.org/10.1002/chin.200317117" @default.
- W2953203604 hasPublicationYear "2003" @default.
- W2953203604 type Work @default.
- W2953203604 sameAs 2953203604 @default.
- W2953203604 citedByCount "0" @default.
- W2953203604 crossrefType "journal-article" @default.
- W2953203604 hasAuthorship W2953203604A5001000707 @default.
- W2953203604 hasAuthorship W2953203604A5004330222 @default.
- W2953203604 hasAuthorship W2953203604A5012291954 @default.
- W2953203604 hasAuthorship W2953203604A5028854670 @default.
- W2953203604 hasAuthorship W2953203604A5043803761 @default.
- W2953203604 hasAuthorship W2953203604A5056030700 @default.
- W2953203604 hasAuthorship W2953203604A5087208103 @default.
- W2953203604 hasConcept C164126121 @default.
- W2953203604 hasConcept C178790620 @default.
- W2953203604 hasConcept C178910836 @default.
- W2953203604 hasConcept C185592680 @default.
- W2953203604 hasConcept C201194858 @default.
- W2953203604 hasConcept C202751555 @default.
- W2953203604 hasConcept C21951064 @default.
- W2953203604 hasConcept C24961977 @default.
- W2953203604 hasConcept C2779014961 @default.
- W2953203604 hasConcept C2779326954 @default.
- W2953203604 hasConcept C2781081902 @default.
- W2953203604 hasConcept C2781338262 @default.
- W2953203604 hasConcept C519063684 @default.
- W2953203604 hasConcept C55493867 @default.
- W2953203604 hasConcept C71240020 @default.
- W2953203604 hasConceptScore W2953203604C164126121 @default.
- W2953203604 hasConceptScore W2953203604C178790620 @default.
- W2953203604 hasConceptScore W2953203604C178910836 @default.
- W2953203604 hasConceptScore W2953203604C185592680 @default.
- W2953203604 hasConceptScore W2953203604C201194858 @default.
- W2953203604 hasConceptScore W2953203604C202751555 @default.
- W2953203604 hasConceptScore W2953203604C21951064 @default.
- W2953203604 hasConceptScore W2953203604C24961977 @default.
- W2953203604 hasConceptScore W2953203604C2779014961 @default.
- W2953203604 hasConceptScore W2953203604C2779326954 @default.
- W2953203604 hasConceptScore W2953203604C2781081902 @default.
- W2953203604 hasConceptScore W2953203604C2781338262 @default.
- W2953203604 hasConceptScore W2953203604C519063684 @default.
- W2953203604 hasConceptScore W2953203604C55493867 @default.
- W2953203604 hasConceptScore W2953203604C71240020 @default.
- W2953203604 hasLocation W29532036041 @default.
- W2953203604 hasOpenAccess W2953203604 @default.
- W2953203604 hasPrimaryLocation W29532036041 @default.
- W2953203604 isParatext "false" @default.
- W2953203604 isRetracted "false" @default.
- W2953203604 magId "2953203604" @default.
- W2953203604 workType "article" @default.