FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953208314> ?p ?o ?g. }

• W2953208314 abstract "Background: Higher inflammatory load associates with increased risk of cardiovascular events in patients with rheumatoid arthritis (RA). We recently reported that occult atherosclerosis burden on coronary computed tomography angiography (CCTA) predicted long-term cardiovascular events (CVE) in RA above and beyond cardiac risk factors or scores. We further showed that higher cumulative inflammatory burden independently predicted coronary plaque progression. Objectives: To explore whether the duration of exposure to biologic DMARDs and/or statins during the study period mitigates the effect of cumulative inflammatory load on coronary plaque progression. Methods: One hundred-one participants with a baseline CCTA underwent a follow-up evaluation in 83±3.6 months. Plaque burden was reported as segment involvement score (SIS, describing the number of coronary artery segments with plaque per patient) and coronary artery calcium (CAC), quantified by the Agatston method. Robust logistic and linear regression models evaluated effects of predictors on plaque (SIS) progression and CAC change, respectively. Predictors of interest were time-averaged c-reactive protein (CRP), duration of bDMARD exposure (years), duration of statin exposure (years), and their 2- and 3-way interactions. Models were controlled for age and baseline hypertension. Significant interactions were subsequently decomposed and examined based on a median split for the duration of biologic and statin exposure. Results: A significant interaction between inflammation and statin exposure duration was observed for plaque progression p=0.019 (figure 1A); in patients with shorter statin exposure ( 1 year) attenuated that effect [OR=1.37, 95% CI=0.67 to 2.82, p=0.391). Notably, significant three-way interactions were observed between time-averaged CRP, duration of bDMARD exposure and duration of statin exposure on plaque progression [p=0.050] and CAC change [p=0.006]. In patients with shorter biologic exposure ( 1 year), inflammation was not related to plaque progression [OR=1.25, 95% CI=0.48 to 3.31, p=0.65] or CAC change [β=-0.16, 95% CI=-0.43 to 0.21, p=0.52]. In patients with longer biologic exposure ( Conclusion: The relationship between cumulative inflammation, length of treatment with bDMARDs, statins and their ultimate impact on coronary plaque progression in RA are highly nuanced. The effect of the duration of statin exposure on coronary plaque burden progression seems relevant only in the context of insufficient biologic exposure; shorter treatment with statins in that setting allows for significant coronary plaque progression in response to higher cumulative inflammatory load. In contrast, longer statin exposure attenuates that risk. Disclosure of Interests: George Karpouzas Grant/research support from: Pfizer, Consultant for: Sanofi-Genzyme-Regeneron, Janssen, Roche-Genentech, Pfizer, Speakers bureau: BMS, Sanofi-Genzyme-Regeneron, Janssen, Roche-Genentech, Sarah Ormseth: None declared, Elizabeth Hernandez: None declared, Matthew Budoff: None declared" @default.
• W2953208314 created "2019-06-27" @default.
• W2953208314 creator A5003628825 @default.
• W2953208314 creator A5033594033 @default.
• W2953208314 creator A5079665496 @default.
• W2953208314 creator A5085071616 @default.
• W2953208314 date "2019-06-01" @default.
• W2953208314 modified "2023-09-27" @default.
• W2953208314 title "FRI0051 DURATION OF EXPOSURE TO BIOLOGICS AND STATINS MODERATES THE EFFECTS OF CUMULATIVE INFLAMMATION ON CORONARY ATHEROSCLEROSIS PROGRESSION IN RHEUMATOID ARTHRITIS" @default.
• W2953208314 doi "https://doi.org/10.1136/annrheumdis-2019-eular.7567" @default.
• W2953208314 hasPublicationYear "2019" @default.
• W2953208314 type Work @default.
• W2953208314 sameAs 2953208314 @default.
• W2953208314 citedByCount "0" @default.
• W2953208314 crossrefType "proceedings-article" @default.
• W2953208314 hasAuthorship W2953208314A5003628825 @default.
• W2953208314 hasAuthorship W2953208314A5033594033 @default.
• W2953208314 hasAuthorship W2953208314A5079665496 @default.
• W2953208314 hasAuthorship W2953208314A5085071616 @default.
• W2953208314 hasBestOaLocation W29532083141 @default.
• W2953208314 hasConcept C126322002 @default.
• W2953208314 hasConcept C164705383 @default.
• W2953208314 hasConcept C2776839432 @default.
• W2953208314 hasConcept C2776914184 @default.
• W2953208314 hasConcept C2777575956 @default.
• W2953208314 hasConcept C71924100 @default.
• W2953208314 hasConceptScore W2953208314C126322002 @default.
• W2953208314 hasConceptScore W2953208314C164705383 @default.
• W2953208314 hasConceptScore W2953208314C2776839432 @default.
• W2953208314 hasConceptScore W2953208314C2776914184 @default.
• W2953208314 hasConceptScore W2953208314C2777575956 @default.
• W2953208314 hasConceptScore W2953208314C71924100 @default.
• W2953208314 hasLocation W29532083141 @default.
• W2953208314 hasOpenAccess W2953208314 @default.
• W2953208314 hasPrimaryLocation W29532083141 @default.
• W2953208314 hasRelatedWork W1491972294 @default.
• W2953208314 hasRelatedWork W1982134196 @default.
• W2953208314 hasRelatedWork W2030022864 @default.
• W2953208314 hasRelatedWork W2312192838 @default.
• W2953208314 hasRelatedWork W2395427622 @default.
• W2953208314 hasRelatedWork W2414261154 @default.
• W2953208314 hasRelatedWork W2767820760 @default.
• W2953208314 hasRelatedWork W2802446694 @default.
• W2953208314 hasRelatedWork W2899842522 @default.
• W2953208314 hasRelatedWork W2956255851 @default.
• W2953208314 hasRelatedWork W2996398337 @default.
• W2953208314 hasRelatedWork W2997203125 @default.
• W2953208314 hasRelatedWork W3012314014 @default.
• W2953208314 hasRelatedWork W3017066135 @default.
• W2953208314 hasRelatedWork W3035422390 @default.
• W2953208314 hasRelatedWork W3035464314 @default.
• W2953208314 hasRelatedWork W3042700127 @default.
• W2953208314 hasRelatedWork W3106553147 @default.
• W2953208314 hasRelatedWork W3112759177 @default.
• W2953208314 hasRelatedWork W3183415643 @default.
• W2953208314 isParatext "false" @default.
• W2953208314 isRetracted "false" @default.
• W2953208314 magId "2953208314" @default.
• W2953208314 workType "article" @default.